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| - | [[Image:1utf.gif|left|200px]]<br /> | + | #REDIRECT [[4v4f]] This PDB entry is obsolete and replaced by 4v4f |
| - | <applet load="1utf" size="450" color="white" frame="true" align="right" spinBox="true"
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| - | caption="1utf, resolution 1.90Å" />
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| - | '''THE STRUCTURE OF THE TRP RNA-BINDING ATTENUATION PROTEIN (TRAP) BOUND TO A RNA MOLECULE CONTAINING UAGAU REPEATS (PART I)'''<br />
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| - | ==Overview==
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| - | The trp RNA-binding attenuation protein (TRAP) regulates expression of the, tryptophan biosynthetic genes in several Bacilli by binding to the leader, region of the nascent trp mRNA, inhibiting continued transcription. The 11, subunit TRAP molecule is active in complex with tryptophan, and binds, consequently an RNA target segment consisting of 11 (G/U)AG triplets, each, separated by two or three non-conserved "spacer" nucleotides. Here, we, report the first crystal structures of TRAP in a complex with RNA, containing UAG triplets separated by two nucleotides and in a complex with, RNA containing GAG triplets separated by three nucleotides. Comparison, with known structures of TRAP-RNA complexes shows that both substitution, of G-1 with U-1 in the triplet and addition of an extra spacer ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15050822 (full description)]]
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| - | ==About this Structure==
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| - | 1UTF is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bacillus_stearothermophilus Bacillus stearothermophilus]] with TRP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UTF OCA]].
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| - | ==Reference==
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| - | The interaction of RNA with TRAP: the role of triplet repeats and separating spacer nucleotides., Hopcroft NH, Manfredo A, Wendt AL, Brzozowski AM, Gollnick P, Antson AA, J Mol Biol. 2004 Apr 16;338(1):43-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15050822 15050822]
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| - | [[Category: Bacillus stearothermophilus]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Antson, A.A.]]
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| - | [[Category: Brzozowski, A.M.]]
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| - | [[Category: Gollnick, P.]]
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| - | [[Category: Hopcroft, N.H.]]
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| - | [[Category: Manfredo, A.]]
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| - | [[Category: Wendt, A.L.]]
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| - | [[Category: TRP]]
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| - | [[Category: rna-binding protein]]
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| - | [[Category: transcription attenuation]]
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| - | [[Category: trp rna]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:37:05 2007''
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