6mpp

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'''Unreleased structure'''
 
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The entry 6mpp is ON HOLD until Paper Publication
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==HLA-A*01:01 complex with NRAS Q61K peptide by NMR==
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<StructureSection load='6mpp' size='340' side='right'caption='[[6mpp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mpp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MPP FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpp OCA], [https://pdbe.org/6mpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mpp RCSB], [https://www.ebi.ac.uk/pdbsum/6mpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpp ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[https://www.uniprot.org/uniprot/1A01_HUMAN 1A01_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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Authors: Flores-Solis, D., McShan, A.C., Sgourakis, N.G.
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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Description: MHC-I complex with NRAS Q16K mutation determined by NMR
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*[[MHC 3D structures|MHC 3D structures]]
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Sgourakis, N.G]]
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<references/>
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[[Category: Mcshan, A.C]]
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Flores-Solis, D]]
[[Category: Flores-Solis, D]]
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[[Category: McShan, A C]]
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[[Category: Sgourakis, N G]]
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[[Category: Immune system]]

Current revision

HLA-A*01:01 complex with NRAS Q61K peptide by NMR

PDB ID 6mpp

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