6nud

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m (Protected "6nud" [edit=sysop:move=sysop])
Current revision (09:22, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6nud is ON HOLD
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==Small conformation of ssRNA-bound CRISPR_Csm complex==
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<SX load='6nud' size='340' side='right' viewer='molstar' caption='[[6nud]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nud]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus Streptococcus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NUD FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nud OCA], [https://pdbe.org/6nud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nud RCSB], [https://www.ebi.ac.uk/pdbsum/6nud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nud ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSM2_STRTR CSM2_STRTR] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities. In a heterologous host this Csm effector complex restricts ssRNA phage MS2, suggesting it may target RNA viruses in vivo.<ref>PMID:25458845</ref> Csm functions as a non-specific ssDNase. Base-pairing between crRNA and target RNA to form a ternary Csm complex activates a ssDNase activity; target RNA cleavage suppresses the ssDNase, a temporal control that prevents uncontrolled DNA degradation. Viral RNA transcripts probably tether the Csm complex to the viral genome, recruiting Cas10 ssDNA activity which is able to degrade DNA in the transcription bubble, spatially controlling the DNase activity.<ref>PMID:27105119</ref> This subunit may be involved in monitoring complementarity of crRNA and target RNA.<ref>PMID:27105119</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Streptococcus thermophilus]]
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[[Category: Chiu W]]
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[[Category: Huang Z]]
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[[Category: Li S]]
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[[Category: Pintilie G]]
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[[Category: Zhang K]]
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[[Category: Zhu Y]]

Current revision

Small conformation of ssRNA-bound CRISPR_Csm complex

6nud, resolution 3.50Å

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