6eaz
From Proteopedia
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==Apo structure of the mitochondrial calcium uniporter protein MICU2== | ==Apo structure of the mitochondrial calcium uniporter protein MICU2== | ||
| - | <StructureSection load='6eaz' size='340' side='right' caption='[[6eaz]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='6eaz' size='340' side='right'caption='[[6eaz]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6eaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAZ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6eaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EAZ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eaz OCA], [https://pdbe.org/6eaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eaz RCSB], [https://www.ebi.ac.uk/pdbsum/6eaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eaz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MICU2_MOUSE MICU2_MOUSE] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering (PubMed:24560927).<ref>PMID:23409044</ref> <ref>PMID:24560927</ref> |
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| + | ==See Also== | ||
| + | *[[Calcium uptake protein 3D structures|Calcium uptake protein 3D structures]] | ||
| + | *[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Grabarek Z]] |
| - | [[Category: | + | [[Category: Kamer KJ]] |
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Current revision
Apo structure of the mitochondrial calcium uniporter protein MICU2
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