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6hr8

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==HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution==
==HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution==
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<StructureSection load='6hr8' size='340' side='right' caption='[[6hr8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='6hr8' size='340' side='right'caption='[[6hr8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hr8]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HR8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hr8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus_DSM_2095 Methanothermococcus thermolithotrophicus DSM 2095]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HR8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase_(NADPH) Hydroxymethylglutaryl-CoA reductase (NADPH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.34 1.1.1.34] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hr8 OCA], [https://pdbe.org/6hr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hr8 RCSB], [https://www.ebi.ac.uk/pdbsum/6hr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hr8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hr8 OCA], [http://pdbe.org/6hr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hr8 RCSB], [http://www.ebi.ac.uk/pdbsum/6hr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hr8 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A4V8GZY0_METTL A0A4V8GZY0_METTL]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hr8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hr8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Erb, T J]]
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[[Category: Large Structures]]
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[[Category: Shima, S]]
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[[Category: Methanothermococcus thermolithotrophicus DSM 2095]]
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[[Category: Voegeli, B]]
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[[Category: Erb TJ]]
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[[Category: Wagner, T]]
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[[Category: Shima S]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Voegeli B]]
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[[Category: Hmg-coa]]
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[[Category: Wagner T]]
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[[Category: Isoprenoid]]
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[[Category: Mevalonate biosynthesis]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase]]
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[[Category: Statin]]
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[[Category: Structural rearrangement]]
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Current revision

HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution

PDB ID 6hr8

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