3oro

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==Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)==
==Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)==
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<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3oro' size='340' side='right'caption='[[3oro]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3orp|3orp]], [[3ort|3ort]], [[1mru|1mru]], [[1o6y|1o6y]], [[3ori|3ori]], [[3ork|3ork]], [[3orl|3orl]], [[3orm|3orm]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [https://pdbe.org/3oro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [https://www.ebi.ac.uk/pdbsum/3oro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [http://pdbe.org/3oro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [http://www.ebi.ac.uk/pdbsum/3oro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PKNB_MYCTU PKNB_MYCTU] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:15978616</ref> <ref>PMID:15987910</ref> <ref>PMID:16817899</ref> <ref>PMID:16980473</ref> <ref>PMID:16436437</ref> <ref>PMID:19826007</ref> <ref>PMID:19121323</ref> <ref>PMID:20025669</ref> <ref>PMID:21423706</ref> <ref>PMID:22275220</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mycta]]
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[[Category: Large Structures]]
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[[Category: Alber, T]]
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[[Category: Mycobacterium tuberculosis H37Ra]]
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[[Category: Echols, N]]
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[[Category: Alber T]]
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[[Category: Good, M C]]
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[[Category: Echols N]]
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[[Category: Lombana, T N]]
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[[Category: Good MC]]
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[[Category: Structural genomic]]
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[[Category: Lombana TN]]
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[[Category: Kinase domain]]
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[[Category: Signal transduction]]
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[[Category: Tbsgc]]
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[[Category: Transferase]]
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Current revision

Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)

PDB ID 3oro

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