Complement C5

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<StructureSection load='' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[3pvm]])' scene='70/705685/Cv/1'>
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<StructureSection load='' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[3pvm]])' scene='70/705685/Cv/6'>
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__TOC__
== Function ==
== Function ==
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Mutations in CC5 cause a deficiency leading to severe recurrent infections and are linked to liver fibrosis, Leiner's disease and rheumatoid arthritis.
Mutations in CC5 cause a deficiency leading to severe recurrent infections and are linked to liver fibrosis, Leiner's disease and rheumatoid arthritis.
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</StructureSection>
 
== 3D Structures of complement C5 ==
== 3D Structures of complement C5 ==
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[[Complement C5 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*CC5
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**[[3cu7]] – hCC5 – human <BR />
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**[[3kls]], [[3km9]] – hCC5 + exotoxin 1 <BR />
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**[[3pvm]] – hCC5 + cobra venom factor <BR />
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**[[3prx]] – hCC5 + cobra venom factor + SSL7<BR />
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**[[4a5w]], [[4e0s]] – hCC5 + CC6<BR />
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**[[5i5k]], [[4uu9]] – hCC5 + antibody<BR />
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**[[5b71]] – hCC5 β chain + antibody<BR />
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**[[5hcc]] – hCC5 + complement inhibitor + RACI3<BR />
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**[[5hcd]] – hCC5 + complement inhibitor + RACI2<BR />
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**[[5hce]] – hCC5 + complement inhibitor + RACI1<BR />
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*C345C
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**[[1xwe]] – hCC5 (mutant) - NMR <BR />
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*C5a anaphylatoxin
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**[[1kjs]], [[3hqa]], [[3hqb]] – hCC5 <BR />
 
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**[[4p39]] – hCC5 (mutant)<BR />
 
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**[[5b4p]] – hCC5 + antibody<BR />
 
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**[[4p3a]], [[4p3b]] – mCC5 - mouse <BR />
 
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**[[4wb3]], [[4wb2]] – mCC5 + DNA/RNA <BR />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code 3pvm)

Drag the structure with the mouse to rotate

References

  1. ↑ Fredslund F, Laursen NS, Roversi P, Jenner L, Oliveira CL, Pedersen JS, Nunn MA, Lea SM, Discipio R, Sottrup-Jensen L, Andersen GR. Structure of and influence of a tick complement inhibitor on human complement component 5. Nat Immunol. 2008 Jul;9(7):753-60. Epub 2008 Jun 8. PMID:18536718 doi:10.1038/ni.1625

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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