Monomethylamine methyltransferase
From Proteopedia
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| - | <StructureSection load='1l2q' size='340' side='right' caption=' | + | <StructureSection load='1l2q' size='340' side='right' caption='MtmB complex with pyrrolysine (PDB code [[1l2q]])' scene=''> |
== Function == | == Function == | ||
| - | Monomethyamine methyltransferase (MtmB) initiates methanogenesis from mono-, di- and trimethylamines. The genes contain a UAG codon which is decoded by a special tRNA as [[Pyrrolysine]]. The pyrrolysine activates and optimally orients methylamine for methyl transfer<ref>PMID:15450490</ref>. Pyrrolysine is considered as the 22st amino acid. | + | '''Monomethyamine methyltransferase''' (MtmB) initiates methanogenesis from mono-, di- and trimethylamines. The genes contain a UAG codon which is decoded by a special tRNA as [[Pyrrolysine]]. The pyrrolysine activates and optimally orients methylamine for methyl transfer<ref>PMID:15450490</ref>. Pyrrolysine is considered as the 22st amino acid. |
| - | == | + | == Structural highlights == |
| - | + | Pyrrolysine, encoded by the UAG codon is observed in the active site of MtmB<ref>PMID:12029132</ref>. | |
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== 3D structures of monomethyamine methyltransferase== | == 3D structures of monomethyamine methyltransferase== | ||
Current revision
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References
- ↑ Krzycki JA. Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases. Curr Opin Chem Biol. 2004 Oct;8(5):484-91. doi: 10.1016/j.cbpa.2004.08.012. PMID:15450490 doi:http://dx.doi.org/10.1016/j.cbpa.2004.08.012
- ↑ Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK. A new UAG-encoded residue in the structure of a methanogen methyltransferase. Science. 2002 May 24;296(5572):1462-6. PMID:12029132 doi:10.1126/science.1069556
