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3cep

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(New page: 200px {{Structure |PDB= 3cep |SIZE=350|CAPTION= <scene name='initialview01'>3cep</scene>, resolution 2.10&Aring; |SITE= <scene name='pdbsite=AC1:Cs+Binding+Site+F...)
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[[Image:3cep.jpg|left|200px]]
 
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{{Structure
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==Structure of a tryptophan synthase quinonoid intermediate==
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|PDB= 3cep |SIZE=350|CAPTION= <scene name='initialview01'>3cep</scene>, resolution 2.10&Aring;
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<StructureSection load='3cep' size='340' side='right'caption='[[3cep]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Cs+Binding+Site+For+Residue+B+398'>AC1</scene>, <scene name='pdbsite=AC2:Cs+Binding+Site+For+Residue+B+399'>AC2</scene>, <scene name='pdbsite=AC3:Cs+Binding+Site+For+Residue+B+400'>AC3</scene>, <scene name='pdbsite=AC4:G3h+Binding+Site+For+Residue+A+269'>AC4</scene>, <scene name='pdbsite=AC5:Idm+Binding+Site+For+Residue+A+270'>AC5</scene>, <scene name='pdbsite=AC6:Plp+Binding+Site+For+Residue+B+401'>AC6</scene>, <scene name='pdbsite=AC7:Sri+Binding+Site+For+Residue+B+402'>AC7</scene> and <scene name='pdbsite=AC8:Idm+Binding+Site+For+Residue+B+403'>AC8</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=IDM:INDOLINE'>IDM</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SRI:(2Z)-3-HYDROXY-2-IMINOPROPANOIC+ACID'>SRI</scene>
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<table><tr><td colspan='2'>[[3cep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CEP FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= trpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium]), trpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=G3P:SN-GLYCEROL-3-PHOSPHATE'>G3P</scene>, <scene name='pdbligand=IDM:INDOLINE'>IDM</scene>, <scene name='pdbligand=MH6:3-HYDROXY-2-IMINOPROPANOIC+ACID'>MH6</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00346 trp_synt_A], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0031 CysK], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04346 PRK04346]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cep OCA], [https://pdbe.org/3cep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cep RCSB], [https://www.ebi.ac.uk/pdbsum/3cep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cep ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cep OCA], [http://www.ebi.ac.uk/pdbsum/3cep PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3cep RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/3cep_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cep ConSurf].
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<div style="clear:both"></div>
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'''Structure of a tryptophan synthase quinonoid intermediate'''
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==See Also==
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*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3CEP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEP OCA].
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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==Reference==
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[[Category: Barends TRM]]
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Structure and Mechanistic Implications of a Tryptophan Synthase Quinonoid Intermediate., Barends TR, Domratcheva T, Kulik V, Blumenstein L, Niks D, Dunn MF, Schlichting I, Chembiochem. 2008 Mar 20;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18351684 18351684]
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[[Category: Blumenstein L]]
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[[Category: Protein complex]]
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[[Category: Domratcheva T]]
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[[Category: Salmonella typhimurium]]
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[[Category: Dunn MF]]
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[[Category: Tryptophan synthase]]
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[[Category: Kulik V]]
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[[Category: Barends, T R.M.]]
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[[Category: Schlichting I]]
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[[Category: Blumenstein, L.]]
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[[Category: Domratcheva, T.]]
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[[Category: Dunn, M F.]]
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[[Category: Kulik, V.]]
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[[Category: Schlichting, I.]]
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[[Category: allosteric enzyme]]
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[[Category: amino-acid biosynthesis]]
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[[Category: aromatic amino acid biosynthesis]]
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[[Category: carbon-oxygen lyase]]
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[[Category: lyase]]
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[[Category: pyridoxal phosphate]]
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[[Category: tryptophan biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 12:00:06 2008''
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Current revision

Structure of a tryptophan synthase quinonoid intermediate

PDB ID 3cep

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