D-alanine-D-alanine ligase

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== Structural highlights ==
== Structural highlights ==
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DDL structure contains <scene name='55/552270/Cv/5'>3 α/β domains</scene>. The <scene name='55/552270/Cv/6'>ADP-binding site</scene> is found between domains 1 and 2.<ref>PMID:17015835</ref>
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DDL structure contains <scene name='55/552270/Cv/5'>3 α/β domains</scene> ({{Template:ColorKey_Helix}},{{Template:ColorKey_Strand}},{{Template:ColorKey_Loop}}, {{Template:ColorKey_Turn}}). The <scene name='55/552270/Cv/6'>ADP-binding site</scene> is found between domains 1 and 2.<ref>PMID:17015835</ref>
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</StructureSection>
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==3D structures of D-alanine-D-alanine ligase==
==3D structures of D-alanine-D-alanine ligase==
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[[D-alanine-D-alanine ligase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*D-alanine-D-alanine ligase
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**[[2fb9]] – DDL – ''Thermus caldophilus'' <br />
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**[[2yzg]] – TtDDL – ''Thermus thermophilus'' <br />
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**[[2i80]], [[2i87]] – SaDDL – ''Staphylococcus aureus'' <br />
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**[[2pvp]] – DDL – ''Helicobacter pylori'' <br />
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**[[3e5n]] – XoDDL – ''Xanthomonas oryzae''<br />
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**[[3lwb]] – DDL – ''Mycobacterium tuberculosis''<br />
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**[[3k3p]] – DDL – ''Streptococcus mutans'' <br />
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**[[3r23]] – BaDDL – ''Bacillus anthracis'' <br />
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**[[3tqt]] – DDL – ''Coxiella burnetii''<br />
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**[[3v4z]], [[4zqi]] – DDL – ''Yersinia pestis'' <br />
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**[[4egq]] – DDL – ''Burkholderia pseudomallei'' <br />
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**[[4egj]] – DDL – ''Burkholderia xenovorans'' <br />
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**[[4eg0]] – DDL – ''Burkholderia ambifaria'' <br />
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**[[2dln]] - EcDDL – ''Escherichia coli''<br />
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**[[3i12]] – StDDL – ''Salmonella typhimurium''<br />
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**[[5d8d]], [[5dmx]] – DDL – ''Acinetobacter baumannii'' <br />
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*D-alanine-D-alanine ligase complex
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**[[2i8c]] – SaDDL + ADP <br />
 
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**[[3n8d]] – SaDDL (mutant) + ANP <br />
 
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**[[2zdg]] – TtDDL + ADP <br />
 
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**[[2yzm]] – TtDDL + D-alanine <br />
 
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**[[2yzn]] – TtDDL + AMPPNP <br />
 
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**[[2zdh]] – TtDDL + D-alanine + ADP<br />
 
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**[[2zdq]] – TtDDL + D-alanine + ATP<br />
 
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**[[3r5x]] – BaDDL + ATP <br />
 
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**[[3q1k]] – StDDL + ADP <br />
 
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**[[5bpf]] – YpDDL + ADP <br />
 
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**[[5bph]] – YpDDL + AMP <br />
 
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**[[5c1o]] – YpDDL + AMPPNP <br />
 
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**[[5c1p]] – YpDDL + D-alanine-D-alanine + ADP<br />
 
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**[[4fu0]] – DDL + ADP – ''Enterococcus faecalis''<br />
 
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**[[4l1k]] – XoDDL + AMPPNP <br />
 
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**[[4me6]] – XoDDL (mutant) + ADP <br />
 
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**[[3rfc]] – XoDDL (mutant) + ADP <br />
 
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**[[3r5f]] – XoDDL (mutant) + ATP <br />
 
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**[[1iov]] – EcDDL + ADP + phosphoryl phosphonate <br />
 
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**[[1iow]] – EcDDL (mutant) + ADP + phosphoryl phosphonate <br />
 
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**[[4c5a]] – EcDDL + ADP + cycloserine phosphate + peptide<br />
 
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**[[4c5b]], [[4c5c]] – EcDDL + D-alanine-D-alanine + ADP<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of D-alanine-D-alanine ligase dimer complex with ADP (stick model), sulfate and Mg+2 ion (green) (PDB entry 2i8c)

Drag the structure with the mouse to rotate

References

  1. ↑ Fan C, Moews PC, Walsh CT, Knox JR. Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution. Science. 1994 Oct 21;266(5184):439-43. PMID:7939684
  2. ↑ Liu S, Chang JS, Herberg JT, Horng MM, Tomich PK, Lin AH, Marotti KR. Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15178-83. Epub 2006 Oct 2. PMID:17015835

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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