3ckl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px {{Structure |PDB= 3ckl |SIZE=350|CAPTION= <scene name='initialview01'>3ckl</scene>, resolution 2.0&Aring; |SITE= <scene name='pdbsite=AC1:Stl+Binding+Site+F...)
Current revision (12:29, 30 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ckl.jpg|left|200px]]
 
-
{{Structure
+
==Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol==
-
|PDB= 3ckl |SIZE=350|CAPTION= <scene name='initialview01'>3ckl</scene>, resolution 2.0&Aring;
+
<StructureSection load='3ckl' size='340' side='right'caption='[[3ckl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Stl+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Stl+Binding+Site+For+Residue+B+501'>AC2</scene>, <scene name='pdbsite=AC3:A3p+Binding+Site+For+Residue+A+601'>AC3</scene> and <scene name='pdbsite=AC4:A3p+Binding+Site+For+Residue+B+601'>AC4</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene>
+
<table><tr><td colspan='2'>[[3ckl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKL FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
|GENE= SULT1B1, ST1B2, SULT1B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00685 Sulfotransfer_1]</span>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckl OCA], [https://pdbe.org/3ckl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckl RCSB], [https://www.ebi.ac.uk/pdbsum/3ckl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckl ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckl OCA], [http://www.ebi.ac.uk/pdbsum/3ckl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3ckl RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/ST1B1_HUMAN ST1B1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.<ref>PMID:9443824</ref> <ref>PMID:9463486</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckl_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ckl ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol'''
+
==See Also==
-
 
+
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
3CKL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Bochkarev A]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Dong, A.]]
+
[[Category: Dong A]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards AM]]
-
[[Category: Kozieradzki, I.]]
+
[[Category: Kozieradzki I]]
-
[[Category: Loppnau, P.]]
+
[[Category: Loppnau P]]
-
[[Category: Min, J.]]
+
[[Category: Min J]]
-
[[Category: Pan, P W.]]
+
[[Category: Pan PW]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Tempel W]]
-
[[Category: Tempel, W.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: cytoplasm]]
+
-
[[Category: human cytosolic sulfotransferase]]
+
-
[[Category: lipid metabolism]]
+
-
[[Category: polymorphism]]
+
-
[[Category: resveratrol]]
+
-
[[Category: sgc]]
+
-
[[Category: steroid metabolism]]
+
-
[[Category: structural genomic]]
+
-
[[Category: structural genomics consortium]]
+
-
[[Category: sult1b1]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 12:00:21 2008''
+

Current revision

Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol

PDB ID 3ckl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ckl"
Personal tools