6nfy
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of nonphosphorylated, HPK1 kinase domain in complex with sunitinib in the inactive state.== | |
| + | <StructureSection load='6nfy' size='340' side='right'caption='[[6nfy]], [[Resolution|resolution]] 2.17Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6nfy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NFY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfy OCA], [https://pdbe.org/6nfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nfy RCSB], [https://www.ebi.ac.uk/pdbsum/6nfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Cronin | + | </StructureSection> |
| - | [[Category: Johnson | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cronin CN]] | ||
| + | [[Category: Johnson E]] | ||
| + | [[Category: McTigue M]] | ||
Current revision
Crystal structure of nonphosphorylated, HPK1 kinase domain in complex with sunitinib in the inactive state.
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