6e0o
From Proteopedia
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==Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with pppA[3'-5']pA== | ==Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with pppA[3'-5']pA== | ||
| - | <StructureSection load='6e0o' size='340' side='right' caption='[[6e0o]], [[Resolution|resolution]] 1.25Å' scene=''> | + | <StructureSection load='6e0o' size='340' side='right'caption='[[6e0o]], [[Resolution|resolution]] 1.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6e0o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0O OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6e0o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica_ATCC_13253_=_NBRC_12535 Elizabethkingia meningoseptica ATCC 13253 = NBRC 12535]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E0O FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0o OCA], [https://pdbe.org/6e0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e0o RCSB], [https://www.ebi.ac.uk/pdbsum/6e0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0o ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDNE_ELIME CDNE_ELIME] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type I-A(GA) CBASS system (PubMed:32839535).<ref>PMID:32839535</ref> Cyclic dinucleotide synthase that catalyzes the synthesis of 3'3'-cyclic GMP-AMP (cGAMP) from GTP and ATP, and of c-di-AMP and c-di-GMP, that are second messengers for cell signal transduction.<ref>PMID:30787435</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Elizabethkingia meningoseptica ATCC 13253 = NBRC 12535]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Eaglesham JB]] |
| - | [[Category: | + | [[Category: King DS]] |
| - | [[Category: | + | [[Category: Kranzusch PJ]] |
| - | [[Category: | + | [[Category: Lee ASY]] |
| - | [[Category: | + | [[Category: Mekalanos JJ]] |
| - | [[Category: | + | [[Category: Morehouse BR]] |
| - | [[Category: | + | [[Category: Nieminen EA]] |
| - | [[Category: | + | [[Category: Whiteley AT]] |
| - | [[Category: | + | [[Category: De Oliveira Mann CC]] |
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Current revision
Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with pppA[3'-5']pA
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