6glp

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==Crystal structure of hMTH1 N33G in complex with LW14 in the presence of acetate==
==Crystal structure of hMTH1 N33G in complex with LW14 in the presence of acetate==
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<StructureSection load='6glp' size='340' side='right' caption='[[6glp]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='6glp' size='340' side='right'caption='[[6glp]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6glp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GLP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6glp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GLP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BU8:1~{H}-imidazo[4,5-b]pyridin-2-amine'>BU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6glp OCA], [http://pdbe.org/6glp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6glp RCSB], [http://www.ebi.ac.uk/pdbsum/6glp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6glp ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BU8:1~{H}-imidazo[4,5-b]pyridin-2-amine'>BU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6glp OCA], [https://pdbe.org/6glp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6glp RCSB], [https://www.ebi.ac.uk/pdbsum/6glp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6glp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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==See Also==
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*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caflisch, A]]
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[[Category: Homo sapiens]]
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[[Category: Eberle, S A]]
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[[Category: Large Structures]]
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[[Category: Sledz, P]]
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[[Category: Caflisch A]]
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[[Category: Wiedmer, L]]
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[[Category: Eberle SA]]
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[[Category: Complex]]
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[[Category: Sledz P]]
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[[Category: Dna repair]]
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[[Category: Wiedmer L]]
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[[Category: Fragment]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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Current revision

Crystal structure of hMTH1 N33G in complex with LW14 in the presence of acetate

PDB ID 6glp

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