5xln

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==Crystal structure of the TRS_UNE-T and 4EHP complex==
==Crystal structure of the TRS_UNE-T and 4EHP complex==
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<StructureSection load='5xln' size='340' side='right' caption='[[5xln]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5xln' size='340' side='right'caption='[[5xln]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xln]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XLN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XLN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xln]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XLN FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EIF4E2, EIF4EL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xln OCA], [https://pdbe.org/5xln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xln RCSB], [https://www.ebi.ac.uk/pdbsum/5xln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xln ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xln OCA], [http://pdbe.org/5xln PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xln RCSB], [http://www.ebi.ac.uk/pdbsum/5xln PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xln ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IF4E2_HUMAN IF4E2_HUMAN]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).[UniProtKB:Q8BMB3]<ref>PMID:17368478</ref> <ref>PMID:22751931</ref> <ref>PMID:25624349</ref> <ref>PMID:9582349</ref>
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[https://www.uniprot.org/uniprot/IF4E2_HUMAN IF4E2_HUMAN] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).[UniProtKB:Q8BMB3]<ref>PMID:17368478</ref> <ref>PMID:22751931</ref> <ref>PMID:25624349</ref> <ref>PMID:9582349</ref>
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Threonine--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: Hwang, J]]
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[[Category: Hwang J]]
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[[Category: Kim, M H]]
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[[Category: Kim MH]]
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[[Category: Nguyen, L T]]
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[[Category: Nguyen LT]]
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[[Category: Complex]]
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[[Category: Rna binding protein-ligase complex]]
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[[Category: Tr]]
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Current revision

Crystal structure of the TRS_UNE-T and 4EHP complex

PDB ID 5xln

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