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6aw9
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==2.55A resolution structure of SAH bound catechol O-methyltransferase (COMT) L136M from Nannospalax galili== | ==2.55A resolution structure of SAH bound catechol O-methyltransferase (COMT) L136M from Nannospalax galili== | ||
| - | <StructureSection load='6aw9' size='340' side='right' caption='[[6aw9]], [[Resolution|resolution]] 2.55Å' scene=''> | + | <StructureSection load='6aw9' size='340' side='right'caption='[[6aw9]], [[Resolution|resolution]] 2.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6aw9]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6aw9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Nannospalax_galili Nannospalax galili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AW9 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw9 OCA], [https://pdbe.org/6aw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aw9 RCSB], [https://www.ebi.ac.uk/pdbsum/6aw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A452CSQ2_NANGA A0A452CSQ2_NANGA] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[ARBA:ARBA00003256] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Battaile | + | [[Category: Nannospalax galili]] |
| - | [[Category: Deng | + | [[Category: Battaile KP]] |
| - | [[Category: Hanzlik | + | [[Category: Deng Y]] |
| - | [[Category: Lovell | + | [[Category: Hanzlik RP]] |
| - | [[Category: Mehzabeen | + | [[Category: Lovell S]] |
| - | [[Category: Moskovitz | + | [[Category: Mehzabeen N]] |
| - | [[Category: Shams | + | [[Category: Moskovitz J]] |
| - | + | [[Category: Shams I]] | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
2.55A resolution structure of SAH bound catechol O-methyltransferase (COMT) L136M from Nannospalax galili
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