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6cqa

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==E. coli DHFR complex with inhibitor AMPQD==
==E. coli DHFR complex with inhibitor AMPQD==
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<StructureSection load='6cqa' size='340' side='right' caption='[[6cqa]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='6cqa' size='340' side='right'caption='[[6cqa]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CQA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CQA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PQD:7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine'>PQD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PQD:7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine'>PQD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cqa OCA], [https://pdbe.org/6cqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cqa RCSB], [https://www.ebi.ac.uk/pdbsum/6cqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cqa ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cqa OCA], [http://pdbe.org/6cqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cqa RCSB], [http://www.ebi.ac.uk/pdbsum/6cqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cqa ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6cqa" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6cqa" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
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[[Category: Benach, J]]
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[[Category: Benach J]]
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[[Category: Cao, H]]
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[[Category: Cao H]]
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[[Category: Koss, J]]
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[[Category: Koss J]]
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[[Category: Morisco, L]]
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[[Category: Morisco L]]
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[[Category: Rodrigues, J]]
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[[Category: Rodrigues J]]
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[[Category: Shakhnovich, E]]
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[[Category: Shakhnovich E]]
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[[Category: Skolnick, J]]
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[[Category: Skolnick J]]
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[[Category: Wasserman, S]]
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[[Category: Wasserman S]]
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[[Category: Complex]]
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[[Category: Dhfr]]
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[[Category: Inhibitor]]
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[[Category: Oxidoreductase]]
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Current revision

E. coli DHFR complex with inhibitor AMPQD

PDB ID 6cqa

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