6g5g

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==Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 2==
==Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 2==
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<StructureSection load='6g5g' size='340' side='right' caption='[[6g5g]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='6g5g' size='340' side='right'caption='[[6g5g]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6g5g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G5G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6g5g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G5G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">botB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5g OCA], [https://pdbe.org/6g5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g5g RCSB], [https://www.ebi.ac.uk/pdbsum/6g5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5g OCA], [http://pdbe.org/6g5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g5g RCSB], [http://www.ebi.ac.uk/pdbsum/6g5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5g ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
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[https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6g5g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6g5g" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus botulinus van ermengem 1896]]
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[[Category: Clostridium botulinum]]
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[[Category: Bontoxilysin]]
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[[Category: Homo sapiens]]
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[[Category: Beard, M]]
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[[Category: Large Structures]]
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[[Category: Carre, D]]
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[[Category: Beard M]]
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[[Category: Dong, M]]
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[[Category: Carre D]]
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[[Category: Elliot, M]]
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[[Category: Dong M]]
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[[Category: Favre-Guilmard, C]]
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[[Category: Elliot M]]
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[[Category: Kalinichev, M]]
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[[Category: Favre-Guilmard C]]
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[[Category: Krupp, J]]
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[[Category: Kalinichev M]]
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[[Category: Lezmi, S]]
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[[Category: Krupp J]]
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[[Category: Liu, S M]]
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[[Category: Lezmi S]]
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[[Category: Maignel, J]]
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[[Category: Liu SM]]
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[[Category: Masuyer, G]]
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[[Category: Maignel J]]
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[[Category: Mir, I]]
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[[Category: Masuyer G]]
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[[Category: Nicoleau, C]]
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[[Category: Mir I]]
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[[Category: Palan, S]]
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[[Category: Nicoleau C]]
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[[Category: Perier, C]]
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[[Category: Palan S]]
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[[Category: Raban, E]]
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[[Category: Perier C]]
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[[Category: Stenmark, P]]
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[[Category: Raban E]]
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[[Category: Botulinum toxin]]
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[[Category: Stenmark P]]
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[[Category: Neurotoxin]]
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[[Category: Protein engineering]]
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[[Category: Receptor binding]]
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[[Category: Toxin]]
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Current revision

Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 2

PDB ID 6g5g

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