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| - | | + | #REDIRECT [[6s73]] This PDB entry is obsolete and replaced by 6s73 |
| - | ==Nek7 bound to purine inhibitor==
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| - | <StructureSection load='6gt1' size='340' side='right' caption='[[6gt1]], [[Resolution|resolution]] 3.50Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6gt1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GT1 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F9N:3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide'>F9N</scene></td></tr>
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| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NEK7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gt1 OCA], [http://pdbe.org/6gt1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gt1 RCSB], [http://www.ebi.ac.uk/pdbsum/6gt1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gt1 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/NEK7_HUMAN NEK7_HUMAN]] Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.<ref>PMID:17101132</ref> <ref>PMID:17586473</ref> <ref>PMID:19414596</ref>
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| - | ==See Also==
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| - | *[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Human]]
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| - | [[Category: Non-specific serine/threonine protein kinase]]
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| - | [[Category: Bayliss, R W]]
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| - | [[Category: Bhatia, C]]
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| - | [[Category: Byrne, M J]]
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| - | [[Category: Cunnison, R F]]
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| - | [[Category: Cell cycle]]
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| - | [[Category: Kinase]]
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| - | [[Category: Mitosis]]
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