3wi3

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==Crystal Structure of the Sld3/Treslin domain from yeast Sld3==
==Crystal Structure of the Sld3/Treslin domain from yeast Sld3==
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<StructureSection load='3wi3' size='340' side='right' caption='[[3wi3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3wi3' size='340' side='right'caption='[[3wi3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wi3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WI3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wi3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WI3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLD3, YGL113W, G2980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wi3 OCA], [http://pdbe.org/3wi3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wi3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wi3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wi3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wi3 OCA], [https://pdbe.org/3wi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wi3 RCSB], [https://www.ebi.ac.uk/pdbsum/3wi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wi3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SLD3_YEAST SLD3_YEAST]] Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins.<ref>PMID:11296242</ref> <ref>PMID:12730134</ref> <ref>PMID:21487389</ref>
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[https://www.uniprot.org/uniprot/SLD3_YEAST SLD3_YEAST] Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins.<ref>PMID:11296242</ref> <ref>PMID:12730134</ref> <ref>PMID:21487389</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The initiation of eukaryotic chromosomal DNA replication requires the formation of an active replicative helicase at the replication origins of chromosomal DNA. Yeast Sld3 and its metazoan counterpart Treslin are the hub proteins mediating protein associations critical for the helicase formation. Here, we show the crystal structure of the central domain of Sld3 that is conserved in Sld3/Treslin family of proteins. The domain consists of two segments with 12 helices and is sufficient to bind to Cdc45, the essential helicase component. The structure model of the Sld3-Cdc45 complex, which is crucial for the formation of the active helicase, is proposed.
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Crystal structure of the homology domain of the eukaryotic DNA replication proteins sld3/treslin.,Itou H, Muramatsu S, Shirakihara Y, Araki H Structure. 2014 Sep 2;22(9):1341-7. doi: 10.1016/j.str.2014.07.001. Epub 2014 Aug, 7. PMID:25126958<ref>PMID:25126958</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3wi3" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
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[[Category: Araki, H]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Itou, H]]
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[[Category: Araki H]]
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[[Category: Shirakihara, Y]]
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[[Category: Itou H]]
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[[Category: Alpha helical]]
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[[Category: Shirakihara Y]]
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[[Category: Cdc45-binding]]
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[[Category: Replication regulator]]
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Current revision

Crystal Structure of the Sld3/Treslin domain from yeast Sld3

PDB ID 3wi3

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