2nd5
From Proteopedia
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==Lysine dimethylated FKBP12== | ==Lysine dimethylated FKBP12== | ||
| - | <StructureSection load='2nd5' size='340' side='right' caption='[[2nd5 | + | <StructureSection load='2nd5' size='340' side='right'caption='[[2nd5]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2nd5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2nd5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ND5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ND5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nd5 OCA], [https://pdbe.org/2nd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nd5 RCSB], [https://www.ebi.ac.uk/pdbsum/2nd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nd5 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Fujiwara | + | [[Category: Fujiwara T]] |
| - | [[Category: Furuita | + | [[Category: Furuita K]] |
| - | [[Category: Hattori | + | [[Category: Hattori Y]] |
| - | [[Category: Ikegami | + | [[Category: Ikegami T]] |
| - | [[Category: Kobayashi | + | [[Category: Kobayashi N]] |
| - | [[Category: Kojima | + | [[Category: Kojima C]] |
| - | [[Category: Ohki | + | [[Category: Ohki I]] |
| - | [[Category: Sebera | + | [[Category: Sebera J]] |
| - | [[Category: Sugiki | + | [[Category: Sugiki T]] |
| - | [[Category: Sychrovsky | + | [[Category: Sychrovsky V]] |
| - | [[Category: Tanaka | + | [[Category: Tanaka Y]] |
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Current revision
Lysine dimethylated FKBP12
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Categories: Homo sapiens | Large Structures | Fujiwara T | Furuita K | Hattori Y | Ikegami T | Kobayashi N | Kojima C | Ohki I | Sebera J | Sugiki T | Sychrovsky V | Tanaka Y
