Dehydroquinase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:26, 5 June 2019) (edit) (undo)
 
(One intermediate revision not shown.)
Line 11: Line 11:
The structure of dehydroquinase type I complex with quinate shows <scene name='55/553960/Cv/10'>DHQD as a homodimer</scene>. The binding of quinate in <scene name='55/553960/Cv/11'>monomer A is slightly different than in monomer B</scene>.<ref>PMID:24437575</ref> <scene name='55/553960/Cv/12'>Click here to see the animation of this scene</scene>.
The structure of dehydroquinase type I complex with quinate shows <scene name='55/553960/Cv/10'>DHQD as a homodimer</scene>. The binding of quinate in <scene name='55/553960/Cv/11'>monomer A is slightly different than in monomer B</scene>.<ref>PMID:24437575</ref> <scene name='55/553960/Cv/12'>Click here to see the animation of this scene</scene>.
-
</StructureSection>
 
==3D structures of dehydroquinase==
==3D structures of dehydroquinase==
 +
[[Dehydroquinase 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*DHQD-I
+
-
 
+
-
**[[1qfe]], [[1gqn]], [[3l2i]], [[3oex]], [[4gfs]], [[4cnn]] – StDHQD – ''Salmonella typhi'' <br />
+
-
**[[3o1n]], [[4guf]] – StDHQD (mutant) <br />
+
-
**[[1sfl]] – SaDHQD – ''Staphylococcus aureus''<br />
+
-
**[[2ocz]] – DHQD – ''Streptococcus pyrogenes''<br />
+
-
**[[2egz]], [[2ysw]] – DHQD – ''Aquifex aeolicus''<br />
+
-
**[[2yr1]] – DHQD – ''Geobacillus kaustophilus''<br />
+
-
**[[2ox1]] – DHQD – ''Archaeoglobus fulgidus''<br />
+
-
**[[3l9c]] – DHQD – ''Streptococcus mutans''<br />
+
-
**[[4ph6]] – DHQD – ''Enterococcus faecalis''<br />
+
-
 
+
-
*DHQD-I complexes
+
-
 
+
-
**[[1l9w]] – StDHQD + amino-dehydroxy-cyclohex-enecarboxylate <br />
+
-
**[[1sfj]] – SaDHQD + dehydroquinic acid <br />
+
-
**[[3js3]] – CdDHQD + amino-dehydroxy-cyclohex-enecarboxylate – ''Clostridium difficile''<br />
+
-
**[[3lb0]] – StDHQD + citrate<br />
+
-
**[[3s42]] – StDHQD + borate + malonate<br />
+
-
**[[3m7w]] – StDHQD + dehydroquinic acid <br />
+
-
**[[4gui]] – StDHQD + quinic acid <br />
+
-
**[[4iuo]] – StDHQD (mutant) + quinic acid <br />
+
-
**[[3nnt]] – StDHQD (mutant) + dehydroquinic acid <br />
+
-
**[[4gug]], [[4guh]] – StDHQD (mutant) + dehydroshikimate<br />
+
-
**[[4guj]] – StDHQD + shikimate<br />
+
-
**[[4clm]], [[4cno]], [[4cnp]] – StDHQD + inhibitor<br />
+
-
**[[4h3d]] – CdDHQD + comenic acid <br />
+
-
**[[4uio]] – DHQD + dehydroquinic acid derivative – ''Salmonella enterica''<br />
+
-
 
+
-
*DHQD-II
+
-
 
+
-
**[[1d0i]], [[1gu0]] – ScDHQD – ''Streptomyces coelicolor'' <br />
+
-
**[[2dhq]], [[1h05]] – MtDHQD – ''Mycobacterium tuberculosis'' <br />
+
-
**[[4ckw]], [[4ckx]], [[4ckz]] – MtDHQD (mutant) <br />
+
-
**[[1gqo]] – DHQD – ''Bacillus subtilis'' <br />
+
-
**[[1uqr]] – DHQD – ''Actinobacillus pleuropneumoniae''<br />
+
-
**[[2uyg]] – DHQD – ''Thermus thermoophilus''<br />
+
-
**[[3lwz]] – DHQD – ''Yersinia pestis''<br />
+
-
**[[3kip]] – DHQD – ''Candida albicans''<br />
+
-
**[[3u80]] – DHQD – ''Bifidobacterium longum'' <br />
+
-
**[[4l8l]] – DHQD – ''Pseudomonas aeruginosa'' <br />
+
-
**[[4rc9]], [[4rhc]], [[4zc1]], [[5b6p]], [[5wrf]], [[5x47]] – DHQD – ''Acinetobacter baumannii''<br />
+
-
 
+
-
*DHQD-II complexes
+
-
**[[1gu1]] – ScDHQD + anhydroquinic acid<br />
 
-
**[[1v1j]] – ScDHQD + anhydrofluoroquinic acid<br />
 
-
**[[2bt4]], [[2cjf]] – ScDHQD + inhibitor<br />
 
-
**[[1gtz]] – ScDHQD (mutant) + dehydroshikimate<br />
 
-
**[[1j2y]] – HpDHQD + dehydroquinic acid – ''Helicobacter pylori''<br />
 
-
**[[1h0s]] – MtDHQD + hydroxyl-imino-quinic acid<br />
 
-
**[[1h0r]] – MtDHQD + anhydroquinic acid<br />
 
-
**[[2c4v]] – HpDHQD + citrate<br />
 
-
**[[2c4w]], [[2c57]], [[2wks]], [[2xb9]], [[2xd9]], [[2xda]], [[4b6r]], [[4b6s]] – HpDHQD + inhibitor<br />
 
-
**[[3n59]] – MtDHQD + dehydroshikimate<br />
 
-
**[[3n8k]] – MtDHQD + citrazinic acid<br />
 
-
**[[2xb8]], [[3n76]], [[3n7a]], [[3n86]], [[3n87]], [[3n8n]], [[2y71]], [[2y76]], [[2y77]], [[4b6o]], [[4b6p]], [[4b6q]], [[4civ]], [[4cix]], [[4ciw]], [[4ciy]], [[4ki7]], [[4kij]], [[4kiu]], [[4kiw]] – MtDHQD + inhibitor<br />
 
-
**[[4cky]], [[4cl0]] – MtDHQD + dehydroquinic acid derivative<br />
 
-
**[[4v0s]] – MtDHQD (mutant) + dehydroquinic acid derivative<br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of dehydroquinase type I complex with quinate and Ni+2 ion (PDB entry 4gui)

Drag the structure with the mouse to rotate

References

  1. ↑ Herrmann KM. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds. Plant Cell. 1995 Jul;7(7):907-919. PMID:12242393 doi:http://dx.doi.org/10.1105/tpc.7.7.907
  2. ↑ Dias MV, Snee WC, Bromfield KM, Payne R, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011 Mar 17. PMID:21410435 doi:10.1042/BJ20110002
  3. ↑ Light SH, Antanasijevic A, Krishna SN, Caffrey M, Anderson WF, Lavie A. Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation. Biochemistry. 2014 Feb 11;53(5):872-80. doi: 10.1021/bi4015506. Epub 2014 Jan 31. PMID:24437575 doi:http://dx.doi.org/10.1021/bi4015506

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Dehydroquinase"
Personal tools