Diphtheria toxin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Diphtheria toxin''' (DT) is a toxin which is secreted by the bacteria causing diphtheria. DT catalyzes the transfer of NAD to a diphthamide residue in the elongation factor-2 and thus inhibiting protein synthesis.<ref>PMID:20040</ref> | + | '''Diphtheria toxin''' (DT) is a toxin which is secreted by the bacteria causing diphtheria. DT catalyzes the transfer of NAD to a diphthamide residue in the elongation factor-2 and thus inhibiting protein synthesis.<ref>PMID:20040</ref> See also [[Toxins]]. |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | <scene name='59/592684/Cv/17'>The biological assembly of Diphtheria toxin is dimer</scene>. DT is proteolitically cleaved into 2 fragments. <scene name='59/592684/Cv/7'>Fragment A contains the catalytic domain (C)</scene> and <scene name='59/592684/Cv/8'>fragment B</scene> contains the <scene name='59/592684/Cv/9'>transmembrane (T)</scene> and <scene name='59/592684/Cv/10'>receptor-binding (R)</scene> domains. <scene name='59/592684/Cv/ | + | <scene name='59/592684/Cv/17'>The biological assembly of Diphtheria toxin is dimer</scene>. DT is proteolitically cleaved into 2 fragments. <scene name='59/592684/Cv/7'>Fragment A contains the catalytic domain (C)</scene> and <scene name='59/592684/Cv/8'>fragment B</scene> contains the <scene name='59/592684/Cv/9'>transmembrane (T)</scene> and <scene name='59/592684/Cv/10'>receptor-binding (R)</scene> domains. <scene name='59/592684/Cv/19'>DT active site</scene> is located in a cleft in the C domain.<ref>PMID:7833807</ref> Water molecules are shown as red spheres. The 2 monomers of DT interact by domain swapping to form a <scene name='59/592684/Cv/16'>compact, globular dimer structure</scene>. |
</StructureSection> | </StructureSection> | ||
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*Diphtheria toxin | *Diphtheria toxin | ||
| - | **[[1sgk]], [[4ow6]] – CbDT – ''Corynebacterium diphtheriae''<br /> | + | **[[1sgk]], [[4ow6]], [[7k7b]], [[7k7c]], [[7k7d]], [[7k7e]] – CbDT – ''Corynebacterium diphtheriae''<br /> |
| - | **[[4ae0]], [[5i82]] – CdDT (mutant)<br /> | + | **[[4ae0]], [[5i82]], [[8g0f]], [[8g0g]] – CdDT (mutant)<br /> |
*Diphtheria toxin complex | *Diphtheria toxin complex | ||
Current revision
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3D structures of diphtheria toxin
Updated on 14-April-2025
References
- ↑ Pappenheimer AM Jr. Diphtheria toxin. Annu Rev Biochem. 1977;46:69-94. PMID:20040 doi:http://dx.doi.org/10.1146/annurev.bi.46.070177.000441
- ↑ Bennett MJ, Choe S, Eisenberg D. Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci. 1994 Sep;3(9):1444-63. PMID:7833807
