Acetylcholinesterase 3D structures

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:18, 3 September 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
== 3D Structures of AChE ==
+
== 3D Structures of [[Acetylcholinesterase]] ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Line 6: Line 6:
*Acetylcholinesterase - AChE native
*Acetylcholinesterase - AChE native
 +
**[[7e3d]], [[8dt2]] – hAChE - human <br />
 +
**[[6o69]] – hAChE (mutant) <br />
**[[3lii]], [[4ey4]], [[4pqe]], [[5hq3]] – hAChE - recombinant human <br />
**[[3lii]], [[4ey4]], [[4pqe]], [[5hq3]] – hAChE - recombinant human <br />
**[[1ea5]], [[2ace]], [[2j3d]], [[1w75]], [[2vt6]], [[2vt7]] – ''Tc''AChE – ''Torpedo californica'' <br />
**[[1ea5]], [[2ace]], [[2j3d]], [[1w75]], [[2vt6]], [[2vt7]] – ''Tc''AChE – ''Torpedo californica'' <br />
-
**[[1qid]] to [[1qim]] - ''Tc''AChE synchrotron radiation damage <br />
+
**[[1qid]], [[1qie]], [[1qif]], [[1qig]], [[1qih]], [[1qii]], [[1qij]], [[1qik]], [[1qil]], [[1qim]] - ''Tc''AChE synchrotron radiation damage <br />
 +
**[[1vzj]] – ''Tc''AChE tetramerization domain <br />
**[[1j06]], [[1maa]], [[5dti]] – mAChE - mouse <br />
**[[1j06]], [[1maa]], [[5dti]] – mAChE - mouse <br />
-
**[[1qo9]] – ''Dm''AChE - ''Drosophila melanogaster'' <br />
+
**[[6xys]] – ''Dm''AChE - ''Drosophila melanogaster'' <br />
**[[1eea]], [[1c2b]], [[1c2o]] – AChE – Electric eel <br />
**[[1eea]], [[1c2b]], [[1c2o]] – AChE – Electric eel <br />
**[[5x61]], [[5ydh]], [[5ydi]] – mmAChE – malaria mosquito<br />
**[[5x61]], [[5ydh]], [[5ydi]] – mmAChE – malaria mosquito<br />
**[[6arx]] – mmAChE (mutant) <br />
**[[6arx]] – mmAChE (mutant) <br />
 +
**[[6uqv]] – PaAChE – ''Pseudomonas aeruginosa'' <br />
 +
**[[6ur0]] – PaAChE (mutant) <br />
*AChE inhibitors (In Different Languages)
*AChE inhibitors (In Different Languages)
Line 55: Line 60:
**[[2ha0]] – mAChE + ketoamyltrimethylammonium <br />
**[[2ha0]] – mAChE + ketoamyltrimethylammonium <br />
**[[2h9y]] – mAChE + TMTFA <br />
**[[2h9y]] – mAChE + TMTFA <br />
-
**[[3zlt]] – mAChE + RVX<br />
 
-
**[[3zlu]] – mAChE + cyclosarin<br />
 
-
**[[3zlv]] – mAChE + tabun + HI-6<br />
 
**[[4bc0]], [[4bc1]] – mAChE + CBDP<br />
**[[4bc0]], [[4bc1]] – mAChE + CBDP<br />
**[[4a16]] – mAChE + huprine <br />
**[[4a16]] – mAChE + huprine <br />
-
**[[4ara]], [[4arb]], [[4a23]], [[4b7z]], [[4b80]], [[4b81]], [[4b82]], [[4b83]], [[4b84]], [[4b85]], [[4btl]], [[5fum]], [[5ehn]], [[5ehq]], [[5ehz]], [[5eia]] - mAChE + inhibitor<br />
+
**[[4ara]], [[4arb]], [[4a23]], [[4b7z]], [[4b80]], [[4b81]], [[4b82]], [[4b83]], [[4b84]], [[4b85]], [[4btl]], [[5fum]], [[5ehn]], [[5ehq]], [[5ehz]], [[5eia]], [[6td2]], [[7qak]], [[7qb4]], [[7qyn]], [[7r02]], [[8orc]] - mAChE + inhibitor<br />
**[[2xuf]], [[2xug]], [[2xuh]], [[2xui]], [[2xuj]], [[2xuk]], [[2xuo]], [[2xup]], [[2xuq]] - mAChE (mutant) + inhibitor<br />
**[[2xuf]], [[2xug]], [[2xuh]], [[2xui]], [[2xuj]], [[2xuk]], [[2xuo]], [[2xup]], [[2xuq]] - mAChE (mutant) + inhibitor<br />
Line 66: Line 68:
**[[4ey5]] – hAChE + huperzine<br />
**[[4ey5]] – hAChE + huperzine<br />
-
**[[4m0e]], [[4m0f]] - hAChE + inhibitor<br />
+
**[[7xn1]] – hAChE + tacrine<br />
 +
**[[7e3h]] – hAChE + donepezil<br />
 +
**[[4m0e]], [[4m0f]], [[6wuv]], [[6wuz]], [[6wvc]], [[6wvp]], [[6wvq]], [[6xta]], [[6zwe]], [[7d9o]], [[7d9p]], [[7d9q]], [[7p1p]], [[8aen]], [[8aev]] - hAChE + inhibitor<br />
 +
**[[6o5v]], [[6o5s]], [[5o5r]], [[6u3p]], [[6u34]], [[6u37]], [[6nea]] - hAChE + oxime reactivator<br />
 +
**[[6o4x]] - hAChE + acridine derivative<br />
 +
**[[7p1n]] - hAChE + oxime derivative <br />
*''Drosophila melanogaster'' AChE active site inhibitors conjugating at the bottom of the active site gorge
*''Drosophila melanogaster'' AChE active site inhibitors conjugating at the bottom of the active site gorge
-
**[[1dx4]], [[1qon]] – ''Dm''AChE + tacrine derivative <br />
+
**[[6xyy]], [[6xyu]] – ''Dm''AChE + tacrine derivative <br />
 +
 
 +
*Other organisms AChE active site inhibitors
 +
 
 +
**[[6tt0]] – AChE + inhibitor – ''Tetronarce californica''<br />
*AChE peripheral site inhibitors conjugating at the surface of the protein
*AChE peripheral site inhibitors conjugating at the surface of the protein
 +
**[[1b41]], [[1f8u]], [[4ey8]] - hAChE + fasciculin 2 <br />
 +
**[[2x8b]] - hAChE + fasciculin 2 + tabun<br />
 +
**[[4bdt]] - hAChE + fasciculin 2 + huprine W<br />
**[[1ku6]], [[1mah]] - mAChE + fasciculin 2 <br />
**[[1ku6]], [[1mah]] - mAChE + fasciculin 2 <br />
**[[1j07]] - mAChE + decidium <br />
**[[1j07]] - mAChE + decidium <br />
**[[1n5m]] - mAChE + gallamine <br />
**[[1n5m]] - mAChE + gallamine <br />
-
**[[1n5r]] - mAChE + propidium <br />
+
**[[1n5r]] - mAChE + propidium <br />
-
**[[1b41]], [[1f8u]], [[4ey8]] - hAChE + fasciculin 2 <br />
+
**[[1fss]] - TcAChE + fasciculin 2 <br />
**[[1fss]] - TcAChE + fasciculin 2 <br />
-
**[[2x8b]] - hAChE + fasciculin 2 + tabun<br />
 
-
**[[4bdt]] - hAChE + fasciculin 2 + huprine W<br />
 
*AChE bis inhibitors spanning the active site gorge
*AChE bis inhibitors spanning the active site gorge
 +
**[[4ey6]] - hAChE + galanthamine<br />
 +
**[[4ey7]], [[5nau]], [[5nap]], [[6o4w]] - hAChE + donepezil derivative<br />
 +
**[[6o50]], [[6o52]] – hAChE + bw284c51 <br />
 +
**[[1q83]], [[1q84]], [[5eie]], [[5eih]] - mAChE + TZ2 derivative <br />
 +
**[[5fkj]] - mAChE + uracil derivative<br />
 +
**[[5foq]] - mAChE + ligand<br />
**[[3i6m]], [[3i6z]], [[1w4l]], [[1w6r]], [[1w76]], [[1dx6]], [[1qti]] – ''Tc''AChE + galanthamine derivative <br />
**[[3i6m]], [[3i6z]], [[1w4l]], [[1w6r]], [[1w76]], [[1dx6]], [[1qti]] – ''Tc''AChE + galanthamine derivative <br />
**[[1zgb]], [[1zgc]] – ''Tc''AChE + tacrine (10) hupyridone <br />
**[[1zgb]], [[1zgc]] – ''Tc''AChE + tacrine (10) hupyridone <br />
**[[2w6c]] – ''Tc''AChE + bis-(-)-nor-meptazinol <br />
**[[2w6c]] – ''Tc''AChE + bis-(-)-nor-meptazinol <br />
**[[2ckm]], [[2cmf]] – ''Tc''AChE + bis-tacrine <br />
**[[2ckm]], [[2cmf]] – ''Tc''AChE + bis-tacrine <br />
-
**[[2cek]] – ''Tc''AChE + N-[8-(1,2,3,4-tetrahydroacridin-9-ylthio)octyl]-1,2,3,4-tetrahydroacridin-9-amine <br />
+
**[[1odc]], [[2cek]], [[1ut6]], [[6h13]], [[6h12]], [[6h14]] - ''Tc''AChE + acridine derivative <br />
-
**[[1ut6]] - ''Tc''AChE + N-9-(1,2,3,4-tetrahydroacridinyl)-1,8-diaminooctane <br />
+
-
**[[1odc]] - ''Tc''AChE + N-4-quinolyl-N-9-(1,2,3,4-tetrahydroacridinyl)-1,8-diaminooctane <br />
+
**[[1h22]], [[1h23]] – ''Tc''AChE + bis-hupyridone <br />
**[[1h22]], [[1h23]] – ''Tc''AChE + bis-hupyridone <br />
-
**[[1hbj]] – ''Tc''AChE + quinoline derivativev <br />
+
**[[1hbj]], [[7ais]], [[7ait]], [[7aiu]], [[7aiv]], [[7aiw]], [[7aix]] – ''Tc''AChE + quinoline derivativev <br />
**[[1e3q]] – ''Tc''AChE + bw284c51 <br />
**[[1e3q]] – ''Tc''AChE + bw284c51 <br />
**[[1eve]] – ''Tc''AChE + e2020 <br />
**[[1eve]] – ''Tc''AChE + e2020 <br />
Line 99: Line 114:
**[[2xud]] – ''Tc''AChE (mutant) + decamethonium<br />
**[[2xud]] – ''Tc''AChE (mutant) + decamethonium<br />
**[[3zv7]] - ''Tc''AChE + bisnorcymserine<br />
**[[3zv7]] - ''Tc''AChE + bisnorcymserine<br />
-
**[[4ey6]] - hAChE + galanthamine<br />
 
-
**[[4ey7]], [[5nau]], [[5nap]] - hAChE + donepezil derivative<br />
 
-
**[[1q83]], [[1q84]], [[5eie]], [[5eih]] - mAChE + TZ2 derivative <br />
 
-
**[[5fkj]] - mAChE + uracil derivative<br />
 
-
**[[5foq]] - mAChE + ligand<br />
 
*AChE organophosphate inhibitors causing irreversible inhibition
*AChE organophosphate inhibitors causing irreversible inhibition
-
**[[2wfz]], [[2wg0]], [[2wg2]], [[1som]] - ''Tc''AChE + soman <br />
+
**[[6cqt]], [[6cqx]], [[6cqz]] - hAChE + VX<br />
-
**[[2wg1]] - ''Tc''AChE + soman + 2-PAM <br />
+
**[[5fpq]] - hAChE + sarin<br />
-
**[[1cfj]] - ''Tc''AChE + sarin, GB <br />
+
**[[6cqu]] – hAChE + HI-6<br />
-
**[[6g17]] – ''Tc''AChE + tabun<br />
+
**[[6cqv]], [[2cqw]] – hAChE + HI-6 + VX<br />
-
**[[1vxo]], [[1vxr]], [[6cqt]] - ''Tc''AChE + VX<br />
+
**[[6cqy]] – hAChE + HI-6 + EMPA<br />
-
**[[1dfp]] - ''Tc''AChE + DFP <br />
+
**[[6wuy]] – hAChE + HI-6 + GA<br />
-
**[[3gel]] - ''Tc''AChE + methyl paraoxon<br />
+
**[[6wv1]] – hAChE + HI-6 + GB<br />
-
**[[2dfp]] – ''Tc''AChE aged<br />
+
**[[5hf6]], [[5hf8]], [[5hf5]] – hAChE (mutant) + paraoxon<br />
 +
**[[5hfa]] – hAChE + paraoxon + 2-PAM<br />
 +
**[[8dt4]], [[8dt5]], [[8dt7]] – hAChE + paraoxon + oxime<br />
 +
**[[5hf9]] – hAChE + paraoxon + HI6<br />
**[[2wu3]] – mAChE + fenamiphos and HI-6 <br />
**[[2wu3]] – mAChE + fenamiphos and HI-6 <br />
**[[2wu4]] – mAChE + fenamiphos and ortho-7 <br />
**[[2wu4]] – mAChE + fenamiphos and ortho-7 <br />
Line 120: Line 133:
**[[2whp]], [[2whq]], [[2whr]], [[5fpp]] – mAChE + sarin and HI-6 <br />
**[[2whp]], [[2whq]], [[2whr]], [[5fpp]] – mAChE + sarin and HI-6 <br />
**[[2y2v]] - mAChE + sarin <br />
**[[2y2v]] - mAChE + sarin <br />
 +
**[[3zlu]] – mAChE + cyclosarin<br />
**[[2jgl]] - mAChE + VX + sarin <br />
**[[2jgl]] - mAChE + VX + sarin <br />
 +
**[[7r0a]] – mAChE + sarin + HI-6<br />
**[[3dl4]], [[3dl7]], [[2c0p]], [[2c0q]] – mAChE + tabun <br />
**[[3dl4]], [[3dl7]], [[2c0p]], [[2c0q]] – mAChE + tabun <br />
**[[2jey]] – mAChE + HLO-7 <br />
**[[2jey]] – mAChE + HLO-7 <br />
**[[2jez]] - mAChE + tabun + HLO-7 <br />
**[[2jez]] - mAChE + tabun + HLO-7 <br />
**[[2jf0]] - mAChE + tabun + Ortho-7 <br />
**[[2jf0]] - mAChE + tabun + Ortho-7 <br />
 +
**[[3zlv]] – mAChE + tabun + HI-6<br />
 +
**[[7r2f]] – mAChE + tabun + inhibitor<br />
**[[2y2u]] - mAChE + VX <br />
**[[2y2u]] - mAChE + VX <br />
 +
**[[7r3c]] - mAChE + VX + inhibitor<br />
**[[2jgi]], [[2jgm]], [[5hcu]] - mAChE + DFP <br />
**[[2jgi]], [[2jgm]], [[5hcu]] - mAChE + DFP <br />
**[[5dtj]] – mAChE + DFP + SP-134<br />
**[[5dtj]] – mAChE + DFP + SP-134<br />
Line 132: Line 150:
**[[2gyv]] - mAChE + Ortho-7 <br />
**[[2gyv]] - mAChE + Ortho-7 <br />
**[[2gyw]] - mAChE + obidoxime <br />
**[[2gyw]] - mAChE + obidoxime <br />
-
**[[6cqt]], [[6cqx]], [[6cqz]] - hAChE + VX<br />
+
**[[3zlt]] – mAChE + RVX<br />
-
**[[5fpq]] - hAChE + sarin<br />
+
**[[7r4e]] - mAChE + RVX + inhibitor<br />
-
**[[6cqu]] – hAChE + HI-6<br />
+
**[[2wfz]], [[2wg0]], [[2wg2]], [[1som]] - ''Tc''AChE + soman <br />
-
**[[6cqv]], [[2cqw]] – hAChE + HI-6 + VX<br />
+
**[[2wg1]] - ''Tc''AChE + soman + 2-PAM <br />
-
**[[6cqy]] – hAChE + HI-6 + EMPA<br />
+
**[[1cfj]] - ''Tc''AChE + sarin, GB <br />
-
**[[5hf6]], [[5hf8]], [[5hf5]] – hAChE (mutant) + paraoxon<br />
+
**[[6g17]] – ''Tc''AChE + tabun<br />
-
**[[5hfa]] – hAChE + paraoxon + 2-PAM<br />
+
**[[1vxo]], [[1vxr]], [[6cqt]] - ''Tc''AChE + VX<br />
-
**[[5hf9]] – hAChE + paraoxon + HI6<br />
+
**[[1dfp]] - ''Tc''AChE + DFP <br />
 +
**[[3gel]] - ''Tc''AChE + methyl paraoxon<br />
 +
**[[2dfp]] – ''Tc''AChE aged<br />
*AChE substrate analogues mimicking the binding of the substrate acetylcholine
*AChE substrate analogues mimicking the binding of the substrate acetylcholine
 +
**[[7rb5]], [[7rb6]] - hAChE + substrate analog<br />
 +
**[[7rb7]] - hAChE + oxime derivative + substrate analog<br />
**[[2ha4]] – mAChE (mutant) + acetylcholine <br />
**[[2ha4]] – mAChE (mutant) + acetylcholine <br />
**[[2ha2]] – mAChE + succinylcholine <br />
**[[2ha2]] – mAChE + succinylcholine <br />
Line 155: Line 177:
**[[2c5f]] – ''Tc''AChE + substrate analog<br />
**[[2c5f]] – ''Tc''AChE + substrate analog<br />
**[[2va9]] - ''Tc''AChE + ‘caged’ arsenocholine<br />
**[[2va9]] - ''Tc''AChE + ‘caged’ arsenocholine<br />
-
**[[4ey7]] – hAChE + donepezil<br />
+
**[[6ur1]], [[6uqz]], [[6uqw]], [[6uqy]], [[6uqx]] – PaAChE (mutant) + thiocholine derivative<br />
*Others...
*Others...
**[[2j4f]] – ''Tc''AChE + Hg <br />
**[[2j4f]] – ''Tc''AChE + Hg <br />
-
**[[1vzj]] – ''Tc''AChE tetramerization domain <br />
+
**[[7b2w]] – ''Tc''AChE + UO2 <br />
 +
**[[7b8e]] – ''Tc''AChE + Ca <br />
 +
**[[7b38]] – ''Tc''AChE + Mg <br />
**[[1jjb]] – ''Tc''AChE + PEG <br />
**[[1jjb]] – ''Tc''AChE + PEG <br />
-
**[[1qie]], [[1qif]], [[1qig]], [[1qih]], [[1qii]], [[1qij]], [[1qik]] – TcAChE synchrotron radiation damage <br />
 
**[[3m3d]] – TcAChE + Xe<br />
**[[3m3d]] – TcAChE + Xe<br />
**[[5ih7]] – TcAChE + methyl-dihydro-indole<br />
**[[5ih7]] – TcAChE + methyl-dihydro-indole<br />

Current revision

3D Structures of Acetylcholinesterase

Updated on 03-September-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Acetylcholinesterase_3D_structures"
Personal tools