6o0h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143== | |
| + | <SX load='6o0h' size='340' side='right' viewer='molstar' caption='[[6o0h]], [[Resolution|resolution]] 3.67Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6o0h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O0H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.67Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=LBG:methyl+3-chloro-5-[(4,6-difluoro[1,1-biphenyl]-3-yl)sulfamoyl]-4-hydroxybenzoate'>LBG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o0h OCA], [https://pdbe.org/6o0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o0h RCSB], [https://www.ebi.ac.uk/pdbsum/6o0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o0h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[ATP-citrate synthase 3D structures|ATP-citrate synthase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tong L]] | ||
| + | [[Category: Wei J]] | ||
Current revision
Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143
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