6o1d
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the centromeric nucleosome with native alpha satellite DNA== | |
| + | <SX load='6o1d' size='340' side='right' viewer='molstar' caption='[[6o1d]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6o1d]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O1D FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.395Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o1d OCA], [https://pdbe.org/6o1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o1d RCSB], [https://www.ebi.ac.uk/pdbsum/6o1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o1d ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Centromere protein 3D structure|Centromere protein 3D structure]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Zhou | + | __TOC__ |
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Zhou B-R]] | ||
Current revision
Cryo-EM structure of the centromeric nucleosome with native alpha satellite DNA
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