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6o20

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'''Unreleased structure'''
 
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The entry 6o20 is ON HOLD
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==Cryo-EM structure of TRPV5 with calmodulin bound==
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<SX load='6o20' size='340' side='right' viewer='molstar' caption='[[6o20]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6o20]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O20 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o20 OCA], [https://pdbe.org/6o20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o20 RCSB], [https://www.ebi.ac.uk/pdbsum/6o20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o20 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV5_RABIT TRPV5_RABIT] Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).[UniProtKB:P69744][UniProtKB:Q9NQA5]<ref>PMID:10085067</ref> <ref>PMID:11035011</ref> <ref>PMID:12574114</ref>
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Authors: Dang, S., van Goor, M.K., Asarnow, D., Wang, Y., Julius, D., Cheng, Y., van der Wijst, J.
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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Description: Cryo-EM structure of TRPV5 with calmodulin bound
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Asarnow, D]]
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<references/>
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[[Category: Cheng, Y]]
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__TOC__
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[[Category: Van Der Wijst, J]]
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</SX>
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[[Category: Wang, Y]]
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[[Category: Bos taurus]]
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[[Category: Dang, S]]
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[[Category: Large Structures]]
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[[Category: Van Goor, M.K]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Julius, D]]
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[[Category: Asarnow D]]
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[[Category: Cheng Y]]
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[[Category: Dang S]]
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[[Category: Julius D]]
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[[Category: Wang Y]]
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[[Category: Van Goor MK]]
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[[Category: Van der Wijst J]]

Current revision

Cryo-EM structure of TRPV5 with calmodulin bound

6o20, resolution 3.30Å

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