6qsc
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6qsc is ON HOLD Authors: Wilk, P., Wator, E., Weiss, M.S. Description: Crystal Structure of Arg470His mutant of Human Prolidase with Mn ions and Gl...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Arg470His mutant of Human Prolidase with Mn ions and GlyPro ligand== | |
| - | + | <StructureSection load='6qsc' size='340' side='right'caption='[[6qsc]], [[Resolution|resolution]] 1.57Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qsc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QSC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.569Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MH2:MANGANESE+ION,+1+HYDROXYL+COORDINATED'>MH2</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qsc OCA], [https://pdbe.org/6qsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qsc RCSB], [https://www.ebi.ac.uk/pdbsum/6qsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qsc ProSAT]</span></td></tr> |
| - | [[Category: Wator | + | </table> |
| - | [[Category: Weiss | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/PEPD_HUMAN PEPD_HUMAN] Defects in PEPD are a cause of prolidase deficiency (PD) [MIM:[https://omim.org/entry/170100 170100]. Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage between the polymorphisms of prolidase and the myotonic dystrophy trait.<ref>PMID:2365824</ref> <ref>PMID:8198124</ref> <ref>PMID:8900231</ref> <ref>PMID:12384772</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PEPD_HUMAN PEPD_HUMAN] Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Wator E]] | ||
| + | [[Category: Weiss MS]] | ||
| + | [[Category: Wilk P]] | ||
Current revision
Crystal Structure of Arg470His mutant of Human Prolidase with Mn ions and GlyPro ligand
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