1upi

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==Mycobacterium tuberculosis rmlC epimerase (Rv3465)==
==Mycobacterium tuberculosis rmlC epimerase (Rv3465)==
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<StructureSection load='1upi' size='340' side='right' caption='[[1upi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='1upi' size='340' side='right'caption='[[1upi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1upi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UPI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1upi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UPI FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-dehydrorhamnose_3,5-epimerase dTDP-4-dehydrorhamnose 3,5-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.13 5.1.3.13] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1upi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upi OCA], [http://pdbe.org/1upi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1upi RCSB], [http://www.ebi.ac.uk/pdbsum/1upi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1upi ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1upi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upi OCA], [https://pdbe.org/1upi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1upi RCSB], [https://www.ebi.ac.uk/pdbsum/1upi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1upi ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RMLC_MYCTU RMLC_MYCTU] Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.<ref>PMID:16472764</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/up/1upi_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/up/1upi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DTDP-4-dehydrorhamnose 3,5-epimerase]]
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[[Category: Large Structures]]
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[[Category: Kantardjieff, K A]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Kim, C Y]]
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[[Category: Kantardjieff KA]]
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[[Category: Lekin, T]]
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[[Category: Kim C-Y]]
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[[Category: Naranjo, C]]
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[[Category: Lekin T]]
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[[Category: Rupp, B]]
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[[Category: Naranjo C]]
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[[Category: Segelke, B W]]
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[[Category: Rupp B]]
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[[Category: Structural genomic]]
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[[Category: Segelke BW]]
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[[Category: Terwilliger, T]]
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[[Category: Terwilliger T]]
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[[Category: Waldo, G S]]
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[[Category: Waldo GS]]
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[[Category: Zemla, A]]
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[[Category: Zemla A]]
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[[Category: Epimerase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Rhamnose pathway]]
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[[Category: Tb]]
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[[Category: Tbsgc]]
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Current revision

Mycobacterium tuberculosis rmlC epimerase (Rv3465)

PDB ID 1upi

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