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3zgg

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==Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with NPE caged UDP-Gal (C222(1) space group)==
==Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with NPE caged UDP-Gal (C222(1) space group)==
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<StructureSection load='3zgg' size='340' side='right' caption='[[3zgg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3zgg' size='340' side='right'caption='[[3zgg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IUG:1-(2-NITROPHENYL)ETHYL+UDP-GALACTOSE'>IUG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zgf|3zgf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IUG:1-(2-NITROPHENYL)ETHYL+UDP-GALACTOSE'>IUG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgg OCA], [http://pdbe.org/3zgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zgg RCSB], [http://www.ebi.ac.uk/pdbsum/3zgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgg OCA], [https://pdbe.org/3zgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgg RCSB], [https://www.ebi.ac.uk/pdbsum/3zgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Glycosyltransferase|Glycosyltransferase]]
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Batot, G O]]
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[[Category: Large Structures]]
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[[Category: Breton, C]]
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[[Category: Batot GO]]
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[[Category: Hindsgaul, O]]
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[[Category: Breton C]]
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[[Category: Imberty, A]]
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[[Category: Hindsgaul O]]
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[[Category: Jorgensen, R]]
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[[Category: Imberty A]]
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[[Category: Palcic, M M]]
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[[Category: Jorgensen R]]
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[[Category: Perez, S]]
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[[Category: Palcic MM]]
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[[Category: Royant, A]]
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[[Category: Perez S]]
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[[Category: Tanaka, H]]
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[[Category: Royant A]]
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[[Category: Catalytic domain]]
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[[Category: Tanaka H]]
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[[Category: Glycosyltransferase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with NPE caged UDP-Gal (C222(1) space group)

PDB ID 3zgg

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