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3j7o

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==Structure of the mammalian 60S ribosomal subunit==
==Structure of the mammalian 60S ribosomal subunit==
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<SX load='3j7o' size='340' side='right' viewer='molstar' caption='[[3j7o]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<SX load='3j7o' size='340' side='right' viewer='molstar' caption='[[3j7o]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j7o]] is a 45 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4w1z 4w1z], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4w20 4w20], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vww 1vww], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwx 1vwx] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j71 3j71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j7o]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4w1z 4w1z], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4w20 4w20], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vww 1vww], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwx 1vwx] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j71 3j71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J7O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3j7p|3j7p]], [[3j7q|3j7q]], [[3j7r|3j7r]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7o OCA], [http://pdbe.org/3j7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j7o RCSB], [http://www.ebi.ac.uk/pdbsum/3j7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7o OCA], [https://pdbe.org/3j7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j7o RCSB], [https://www.ebi.ac.uk/pdbsum/3j7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RL11_PIG RL11_PIG]] Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity). [[http://www.uniprot.org/uniprot/RL40_PIG RL40_PIG]] Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). 60S ribosomal protein L40: component of the 60S subunit of the ribosome (By similarity).
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[https://www.uniprot.org/uniprot/F2Z567_PIG F2Z567_PIG]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Fernandez, I S]]
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[[Category: Fernandez IS]]
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[[Category: Hegde, R S]]
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[[Category: Hegde RS]]
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[[Category: Scheres, S H.W]]
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[[Category: Scheres SHW]]
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[[Category: Voorhees, R M]]
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[[Category: Voorhees RM]]
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[[Category: Mammalian]]
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[[Category: Ribosome]]
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Current revision

Structure of the mammalian 60S ribosomal subunit

3j7o, resolution 3.50Å

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