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Albumin

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The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
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</StructureSection>
 
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== 3D Structures of albumin ==
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== 3D Structures of albumin ==
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[[Albumin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Human serum albumin
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**[[1e78]], [[1bm0]], [[1ao6]], [[1uor]], [[3sqj]], [[4g03]], [[4g04]], [[4k2c]] - hSA – human
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*Human serum albumin binary complex
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**[[2ydf]] – hSA + iophenoxic acid<br />
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**[[2xvq]], [[2xvu]], [[2xw0]], [[2xw1]] - hSA + dansyl derivative<br />
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**[[3lu6]], [[3ju7]], [[3lu8]], [[2bx8]], [[2bxa]], [[2bxb]], [[2bxc]], [[2bxd]], [[2bxe]], [[2bxf ]], [[2bxg]], [[2bxh]], [[2bxi]], [[2bxk]], [[2bxl]], [[2bxm]], [[2bxn]],[[2bxo]], [[2bxp]], [[2bxq]], [[3lu7]], [[4l8u]], [[4l9k]], [[4l9q]], [[4la0]], [[4lb2]], [[4lb9]], [[5ifo]], [[5id9]], [[5id7]], [[5gix]], [[5giy]] – hSA + drug<br />
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**[[4iw1]], [[4iw2]] – hSA + monosaccharide<br />
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**[[3jqz]] – hSA + lidocaine<br />
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**[[3jry]] - hSA + sulfate<br />
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**[[4emx]] – hSA + Cl<br />
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**[[5ifj]], [[5ije]], [[5ij5]], [[5iix]], [[5iiu]], [[5iih]] – hSA + Zn<br />
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**[[4s1y]] – hSA + cisplatin<br />
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**[[1n5u]] - hSA + heme<br />
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**[[3a73]] - hSA + prostaglandin<br />
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**[[2vuf]], [[2vue]] - hSA + bilirubin derivative<br />
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**[[5ujb]] – hSA + MCL-1 inhibitor<br />
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**[[5yoq]] – hSA + phenylbutyrate<br />
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**[[1gni]], [[1gnj]], [[1e7h]], [[1e7e]], [[1e7f]], [[1e7i]], [[1bke]], [[1bj5]], [[3tdl]], [[4e99]], [[4bke]], [[6ezq]] - hSA + fatty acid<br />
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**[[1hk1]] - hSA + thiroxine<br />
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**[[2hk2]], [[1hk3]], [[1hk2]] - hSA (mutant) + thiroxine<br />
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**[[1e7a]], [[1e7b]] - hSA + general anesthetic<br />
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**[[1tf0]] - hSA + peptostreptococcal albumin-binding protein GA module<br />
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**[[2esg]] - hSA + immunoglobulin A1<br />
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**[[1ysx]] - hSA + anti-apoptotic ligand – NMR<BR />
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**[[4hgk]], [[4hgm]], [[5fuo]] – hSA + shark antibody<br />
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**[[5vnw]] – hSA + nanobody<br />
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*Human serum albumin ternary complex
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**[[2xsi]], [[2xvv]], [[2xvw]] – hSA + dansyl derivative + myristic acid<br />
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**[[3cx9]] - hSA + lysophospholipid + myristic acid<br />
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**[[1e7g]] - hSA + fatty acid + myristic acid<br />
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**[[1h9z]], [[1ha2]] - hSA + warfarine + myristic acid<br />
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**[[1e7c]] - hSA + general anesthetic + myristic acid<br />
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**[[1hk4]] - hSA + thiroxine + myristic acid<br />
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**[[1hk5]] - hSA (mutant) + thiroxine + myristic acid<br />
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**[[1o9x]] - hSA + hemin + myristic acid<br />
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**[[3uiv]] - hSA + amantadine + myristic acid<br />
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**[[3b9l]] - hSA + AZT + myristic acid<br />
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**[[2i2z]] - hSA + aspirin + myristic acid<br />
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**[[2i30]] - hSA + salicylic acid + myristic acid<br />
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**[[4z69]] – hSA + palmitate + diclofenac<br />
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**[[5x52]] – hSA + octanoate + acetyl methionine<br />
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**[[3b9m]] - hSA + AZT + salicylic acid + myristic acid<br />
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**[[2vdb]] - hSA + peptostreptococcal albumin-binding protein GA module + naproxen<br />
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**[[4k71]], [[4n0f]] – hSA + Igg receptor + β-2-microglobulin<br />
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**[[4n0u]] – hSA + Igg receptor + β-2-microglobulin + Ig γ-1 chain C<br />
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*Other serum albumins
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**[[3v03]], [[4f5s]] - bSA – bovine<br />
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**[[3v08]], [[4f5t]], [[4f5u]], [[5hoz]] – hoSA – horse<br />
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**[[3v09]], [[4f5v]] – rSA – rabbit<br />
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**[[4luf]], [[5orf]] – sSA – sheep<br />
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**[[5ori]], [[5otb]] – gSA – goat<br />
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**[[3vvj]] – SA – emu<br />
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**[[5ghk]] – SA – dog<br />
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**[[4j2v]] – hoSA + diiodosalicilate<br />
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**[[4jk4]] – bSA + diiodosalicilate<br />
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**[[4luh]] – sSA + diiodosalicilate<br />
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**[[5osw]] – gSA + diiodosalicilate<br />
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**[[4or0]] – bSA + drug<br />
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**[[4ot2]], [[5dqf]], [[5dby]], [[4zbr]], [[4zbq]], [[5v0v]], [[6ci6]] – hoSA + drug<br />
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**[[4po0]] – rSA + drug<br />
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</StructureSection>
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*Albumin
 
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**[[1s6d]] – Alb 8 – sunflower – NMR<BR />
 
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**[[1wba]] – Alb 1 – winged bean<br />
 
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**[[1p8b]] – Alb 1 – pea<br />
 
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**[[1psy]] – Alb – castor bean - NMR<br />
 
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**[[3lp9]] – Alb hemopexin domain – ''Lathyrus sativus''<br />
 
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**[[2lvf]] – Alb – Brazil nut<br />
 
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**[[5dom]] – SA 2S – horseradish tree<br />
 
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**[[5okl]] – ha-Alb<br />
 
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}}
 
'''References'''
'''References'''
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human serum albumin (PDB code 1bm0)

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References

  1. ↑ Liu Y, Chen M, Luo Z, Lin J, Song L. Investigation on the site-selective binding of bovine serum albumin by erlotinib hydrochloride. J Biomol Struct Dyn. 2012 Oct 17. PMID:23072300 doi:10.1080/07391102.2012.726532

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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