6qu9

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(New page: '''Unreleased structure''' The entry 6qu9 is ON HOLD Authors: Jagger, A.M., Heyer-Chauhan, N., Lomas, D.A., Irving, J.A. Description: Fab fragment of an antibody that inhibits polymeri...)
Current revision (05:41, 21 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6qu9 is ON HOLD
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==Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin==
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<StructureSection load='6qu9' size='340' side='right'caption='[[6qu9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qu9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QU9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qu9 OCA], [https://pdbe.org/6qu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qu9 RCSB], [https://www.ebi.ac.uk/pdbsum/6qu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qu9 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ordered aggregates. alpha1-Antitrypsin deficiency is the archetypal serpinopathy and results from the formation and deposition of mutant forms of alpha1-antitrypsin as "polymer" chains in liver tissue. No detailed structural analysis has been performed of this material. Moreover, there is little information on the relevance of well-studied artificially induced polymers to these disease-associated molecules. We have isolated polymers from the liver tissue of Z alpha1-antitrypsin homozygotes (E342K) who have undergone transplantation, labeled them using a Fab fragment, and performed single-particle analysis of negative-stain electron micrographs. The data show structural equivalence between heat-induced and ex vivo polymers and that the intersubunit linkage is best explained by a carboxyl-terminal domain swap between molecules of alpha1-antitrypsin.
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Authors: Jagger, A.M., Heyer-Chauhan, N., Lomas, D.A., Irving, J.A.
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The structural basis for Z alpha1-antitrypsin polymerization in the liver.,Faull SV, Elliston ELK, Gooptu B, Jagger AM, Aldobiyan I, Redzej A, Badaoui M, Heyer-Chauhan N, Rashid ST, Reynolds GM, Adams DH, Miranda E, Orlova EV, Irving JA, Lomas DA Sci Adv. 2020 Oct 21;6(43). pii: 6/43/eabc1370. doi: 10.1126/sciadv.abc1370., Print 2020 Oct. PMID:33087346<ref>PMID:33087346</ref>
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Description: Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Irving, J.A]]
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<div class="pdbe-citations 6qu9" style="background-color:#fffaf0;"></div>
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[[Category: Lomas, D.A]]
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[[Category: Heyer-Chauhan, N]]
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==See Also==
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[[Category: Jagger, A.M]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Heyer-Chauhan N]]
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[[Category: Irving JA]]
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[[Category: Jagger AM]]
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[[Category: Lomas DA]]

Current revision

Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin

PDB ID 6qu9

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