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6eb2

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==HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid==
==HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid==
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<StructureSection load='6eb2' size='340' side='right' caption='[[6eb2]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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<StructureSection load='6eb2' size='340' side='right'caption='[[6eb2]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6eb2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EB2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EB2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6eb2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EB2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J3P:(2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic+acid'>J3P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.493&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene>, <scene name='pdbligand=J3P:(2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic+acid'>J3P</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eb2 OCA], [http://pdbe.org/6eb2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eb2 RCSB], [http://www.ebi.ac.uk/pdbsum/6eb2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eb2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eb2 OCA], [https://pdbe.org/6eb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eb2 RCSB], [https://www.ebi.ac.uk/pdbsum/6eb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eb2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/F2WR52_9HIV1 F2WR52_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6eb2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6eb2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kobe, M]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Kvaratskhelia, M]]
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[[Category: Large Structures]]
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[[Category: Lindenberger, J J]]
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[[Category: Kobe M]]
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[[Category: Allosteric]]
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[[Category: Kvaratskhelia M]]
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[[Category: Hiv]]
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[[Category: Lindenberger JJ]]
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[[Category: Inhibitor]]
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[[Category: Integrase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid

PDB ID 6eb2

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