6q3y

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==Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16i==
==Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16i==
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<StructureSection load='6q3y' size='340' side='right' caption='[[6q3y]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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<StructureSection load='6q3y' size='340' side='right'caption='[[6q3y]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6q3y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q3Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6q3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q3Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HG5:(7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-(phenylmethyl)-7~{H}-pteridin-6-one'>HG5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q3y OCA], [http://pdbe.org/6q3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q3y RCSB], [http://www.ebi.ac.uk/pdbsum/6q3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q3y ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HG5:(7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-(phenylmethyl)-7~{H}-pteridin-6-one'>HG5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q3y OCA], [https://pdbe.org/6q3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q3y RCSB], [https://www.ebi.ac.uk/pdbsum/6q3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q3y ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6q3y" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6q3y" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Edwards, A M]]
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[[Category: Arrowsmith CH]]
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[[Category: Heidenreich, D]]
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[[Category: Bountra C]]
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[[Category: Hoelder, S]]
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[[Category: Edwards AM]]
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[[Category: Knapp, S]]
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[[Category: Heidenreich D]]
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[[Category: Structural genomic]]
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[[Category: Hoelder S]]
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[[Category: Watts, E]]
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[[Category: Knapp S]]
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[[Category: Complex]]
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[[Category: Watts E]]
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[[Category: Gene regulation]]
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[[Category: Inhibitor]]
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[[Category: Sgc]]
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Current revision

Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16i

PDB ID 6q3y

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