1e9a

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==Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A==
==Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A==
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<StructureSection load='1e9a' size='340' side='right' caption='[[1e9a]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='1e9a' size='340' side='right'caption='[[1e9a]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1e9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E9A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1e9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E9A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Z5A:P1-(5-ADENOSYL)P5-(5-(3AZIDO-3-DEOXYTHYMIDYL))PENTAPHOSPHATE'>Z5A</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e2d|1e2d]], [[1e2e|1e2e]], [[1e2f|1e2f]], [[1e2g|1e2g]], [[1e2q|1e2q]], [[1e98|1e98]], [[1e99|1e99]], [[1e9b|1e9b]], [[1e9c|1e9c]], [[1e9d|1e9d]], [[1e9e|1e9e]], [[1e9f|1e9f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Z5A:P1-(5-ADENOSYL)P5-(5-(3AZIDO-3-DEOXYTHYMIDYL))PENTAPHOSPHATE'>Z5A</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9a OCA], [https://pdbe.org/1e9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e9a RCSB], [https://www.ebi.ac.uk/pdbsum/1e9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9a OCA], [http://pdbe.org/1e9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e9a RCSB], [http://www.ebi.ac.uk/pdbsum/1e9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9a ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_HUMAN KTHY_HUMAN] Catalyzes the conversion of dTMP to dTDP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Thymidylate kinase|Thymidylate kinase]]
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: DTMP kinase]]
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[[Category: Large Structures]]
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[[Category: Brundiers, R]]
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[[Category: Brundiers R]]
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[[Category: Goody, R S]]
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[[Category: Goody RS]]
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[[Category: Konrad, M]]
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[[Category: Konrad M]]
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[[Category: Lavie, A]]
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[[Category: Lavie A]]
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[[Category: Ostermann, N]]
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[[Category: Ostermann N]]
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[[Category: Padiyar, S]]
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[[Category: Padiyar S]]
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[[Category: Reintein, J]]
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[[Category: Reintein J]]
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[[Category: Schlichting, I]]
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[[Category: Schlichting I]]
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[[Category: Veit, T]]
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[[Category: Veit T]]
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[[Category: P-loop]]
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[[Category: Phosphotransferase]]
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[[Category: Thymidylate kinase]]
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[[Category: Transferase]]
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Current revision

Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A

PDB ID 1e9a

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