4ajg

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<StructureSection load='4ajg' size='340' side='right'caption='[[4ajg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4ajg' size='340' side='right'caption='[[4ajg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F07:THIENO[3,2-C][1,6]NAPHTHYRIDINE'>F07</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajd|4ajd]], [[4ajf|4ajf]], [[4ajm|4ajm]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [http://pdbe.org/4ajg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [http://www.ebi.ac.uk/pdbsum/4ajg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [https://pdbe.org/4ajg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [https://www.ebi.ac.uk/pdbsum/4ajg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Aharony, D]]
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[[Category: Large Structures]]
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[[Category: Akerud, T]]
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[[Category: Aharony D]]
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[[Category: Albert, J S]]
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[[Category: Akerud T]]
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[[Category: Back, E]]
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[[Category: Albert JS]]
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[[Category: Geschwindner, S]]
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[[Category: Back E]]
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[[Category: Hillertz, P]]
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[[Category: Geschwindner S]]
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[[Category: Horsefeld, R]]
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[[Category: Hillertz P]]
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[[Category: Johansson, P]]
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[[Category: Horsefeld R]]
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[[Category: Scott, C]]
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[[Category: Johansson P]]
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[[Category: Spadola, L]]
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[[Category: Scott C]]
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[[Category: Spear, N]]
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[[Category: Spadola L]]
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[[Category: Tian, G]]
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[[Category: Spear N]]
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[[Category: Tigerstrom, A]]
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[[Category: Tian G]]
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[[Category: Hydrolase]]
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[[Category: Tigerstrom A]]

Current revision

Identification and structural characterization of PDE10 fragment inhibitors

PDB ID 4ajg

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