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| | <StructureSection load='4ak4' size='340' side='right'caption='[[4ak4]], [[Resolution|resolution]] 1.65Å' scene=''> | | <StructureSection load='4ak4' size='340' side='right'caption='[[4ak4]], [[Resolution|resolution]] 1.65Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4ak4]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AK4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4ak4]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AK4 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4akb|4akb]], [[4akc|4akc]], [[4akd|4akd]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ak4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak4 OCA], [http://pdbe.org/4ak4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ak4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ak4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ak4 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ak4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak4 OCA], [https://pdbe.org/4ak4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ak4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ak4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ak4 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN]] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum. [[http://www.uniprot.org/uniprot/LECB4_ARTIN LECB4_ARTIN]] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum (By similarity). | + | [https://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Artocarpus integer]] | | [[Category: Artocarpus integer]] |
| - | [[Category: Abdul-Rahman, P S]] | + | [[Category: Large Structures]] |
| - | [[Category: Cogdell, R J]] | + | [[Category: Abdul-Rahman PS]] |
| - | [[Category: Gabrielsen, M]] | + | [[Category: Cogdell RJ]] |
| - | [[Category: Hashim, O H]] | + | [[Category: Gabrielsen M]] |
| - | [[Category: Othman, S]] | + | [[Category: Hashim OH]] |
| - | [[Category: Lectin]]
| + | [[Category: Othman S]] |
| - | [[Category: Mannose]]
| + | |
| - | [[Category: Plant]]
| + | |
| - | [[Category: Sugar binding protein]]
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| Structural highlights
Function
LECA_ARTIN D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
Publication Abstract from PubMed
Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding.
Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins.,Gabrielsen M, Abdul-Rahman PS, Othman S, Hashim OH, Cogdell RJ Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):709-16. doi:, 10.1107/S2053230X14008966. Epub 2014 May 24. PMID:24915077[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gabrielsen M, Abdul-Rahman PS, Othman S, Hashim OH, Cogdell RJ. Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins. Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):709-16. doi:, 10.1107/S2053230X14008966. Epub 2014 May 24. PMID:24915077 doi:http://dx.doi.org/10.1107/S2053230X14008966
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