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| | <StructureSection load='4a61' size='340' side='right'caption='[[4a61]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='4a61' size='340' side='right'caption='[[4a61]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4a61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A61 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4a61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A61 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mwk|1mwk]], [[4a6j|4a6j]], [[1mwm|1mwm]], [[4a62|4a62]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a61 OCA], [http://pdbe.org/4a61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a61 RCSB], [http://www.ebi.ac.uk/pdbsum/4a61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a61 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a61 OCA], [https://pdbe.org/4a61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a61 RCSB], [https://www.ebi.ac.uk/pdbsum/4a61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a61 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PARM_ECOLX PARM_ECOLX]] Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid. | + | [https://www.uniprot.org/uniprot/PARM_ECOLX PARM_ECOLX] Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bacillus coli migula 1895]] | + | [[Category: Escherichia coli]] |
| - | [[Category: Ent, F van den]] | + | [[Category: Large Structures]] |
| - | [[Category: Gayathri, P]] | + | [[Category: Gayathri P]] |
| - | [[Category: Lowe, J]] | + | [[Category: Lowe J]] |
| - | [[Category: Moller-Jensen, J]] | + | [[Category: Moller-Jensen J]] |
| - | [[Category: Actin-fold]] | + | [[Category: Van den Ent F]] |
| - | [[Category: Plasmid segregation]]
| + | |
| - | [[Category: Transport protein]]
| + | |
| Structural highlights
Function
PARM_ECOLX Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid.
Publication Abstract from PubMed
To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles.
A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation.,Gayathri P, Fujii T, Moller-Jensen J, van den Ent F, Namba K, Lowe J Science. 2012 Oct 25. PMID:23112295[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gayathri P, Fujii T, Moller-Jensen J, van den Ent F, Namba K, Lowe J. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation. Science. 2012 Oct 25. PMID:23112295 doi:http://dx.doi.org/10.1126/science.1229091
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