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| | <StructureSection load='4ats' size='340' side='right'caption='[[4ats]], [[Resolution|resolution]] 3.85Å' scene=''> | | <StructureSection load='4ats' size='340' side='right'caption='[[4ats]], [[Resolution|resolution]] 3.85Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4ats]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atv Atv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ATS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4ats]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidianus_two-tailed_virus Acidianus two-tailed virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ATS FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4art|4art]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.85Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ats FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ats OCA], [http://pdbe.org/4ats PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ats RCSB], [http://www.ebi.ac.uk/pdbsum/4ats PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ats ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ats FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ats OCA], [https://pdbe.org/4ats PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ats RCSB], [https://www.ebi.ac.uk/pdbsum/4ats PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ats ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Atv]] | + | [[Category: Acidianus two-tailed virus]] |
| - | [[Category: Felisberto-Rodrigues, C]]
| + | [[Category: Large Structures]] |
| - | [[Category: Ortiz-Lombardia, M]]
| + | [[Category: Felisberto-Rodrigues C]] |
| - | [[Category: Archaeal virus]]
| + | [[Category: Ortiz-Lombardia M]] |
| - | [[Category: Bicaudavirus]] | + | |
| - | [[Category: Extremophile]] | + | |
| - | [[Category: Hyper-thermostability]] | + | |
| - | [[Category: Viral protein]]
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| Structural highlights
Publication Abstract from PubMed
Acidianus two-tailed virus (ATV) infects crenarchaea of the genus Acidianus living in terrestrial thermal springs at extremely high temperatures and low pH. ATV is a member of the Bicaudaviridae virus family and undergoes extra-cellular development of two tails, a process that is unique in the viral world. To understand this intriguing phenomenon, we have undertaken structural studies of ATV virion proteins and here we present the crystal structure of one of these proteins, ATV[Formula: see text]. ATV[Formula: see text] forms tetramers in solution and a molecular envelope is provided for the tetramer, computed from small-angle X-ray scattering (SAXS) data. The crystal structure has properties typical of hyperthermostable proteins, including a relatively high number of salt bridges. However, the protein also exhibits flexible loops and surface pockets. Remarkably, ATV[Formula: see text] displays a new [Formula: see text] protein fold, consistent with the absence of homologues of this protein in public sequence databases.
Crystal Structure of ATV(ORF273), a New Fold for a Thermo- and Acido-Stable Protein from the Acidianus Two-Tailed Virus.,Felisberto-Rodrigues C, Blangy S, Goulet A, Vestergaard G, Cambillau C, Garrett RA, Ortiz-Lombardia M PLoS One. 2012;7(10):e45847. doi: 10.1371/journal.pone.0045847. Epub 2012 Oct 8. PMID:23056221[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Felisberto-Rodrigues C, Blangy S, Goulet A, Vestergaard G, Cambillau C, Garrett RA, Ortiz-Lombardia M. Crystal Structure of ATV(ORF273), a New Fold for a Thermo- and Acido-Stable Protein from the Acidianus Two-Tailed Virus. PLoS One. 2012;7(10):e45847. doi: 10.1371/journal.pone.0045847. Epub 2012 Oct 8. PMID:23056221 doi:http://dx.doi.org/10.1371/journal.pone.0045847
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