6jls
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Crystal Structure of FMN-dependent Cysteine Decarboxylases TvaF from Thioviridamide Biosynthesis== | |
+ | <StructureSection load='6jls' size='340' side='right'caption='[[6jls]], [[Resolution|resolution]] 2.24Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[6jls]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_olivoviridis Streptomyces olivoviridis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JLS FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24Å</td></tr> | ||
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jls OCA], [https://pdbe.org/6jls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jls RCSB], [https://www.ebi.ac.uk/pdbsum/6jls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jls ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/T2HUM4_9ACTN T2HUM4_9ACTN] | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | The biosynthesis of thioviridamide-like compounds has not been elucidated. Herein, we report that TvaF from the thioviridamide biosynthetic gene cluster is an FMN-dependent cysteine decarboxylase that transforms the C-terminal cysteine of precursor peptides into a thioenol motif and exhibits high substrate flexibility. We resolved the crystal structure of TvaF bound with FMN at 2.24 A resolution. Key residues for FMN binding and catalytic activity of TvaF have been identified and evaluated by mutagenesis studies. | ||
- | + | Characterization of the FMN-Dependent Cysteine Decarboxylase from Thioviridamide Biosynthesis.,Lu J, Li J, Wu Y, Fang X, Zhu J, Wang H Org Lett. 2019 Jun 3. doi: 10.1021/acs.orglett.9b01531. PMID:31184189<ref>PMID:31184189</ref> | |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | [[Category: | + | </div> |
- | [[Category: | + | <div class="pdbe-citations 6jls" style="background-color:#fffaf0;"></div> |
- | [[Category: Li | + | == References == |
- | [[Category: Lu | + | <references/> |
- | [[Category: Wang | + | __TOC__ |
+ | </StructureSection> | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Streptomyces olivoviridis]] | ||
+ | [[Category: Li J]] | ||
+ | [[Category: Lu J]] | ||
+ | [[Category: Wang H]] | ||
+ | [[Category: Zhu J]] |
Current revision
Crystal Structure of FMN-dependent Cysteine Decarboxylases TvaF from Thioviridamide Biosynthesis
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