6qw3

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(New page: '''Unreleased structure''' The entry 6qw3 is ON HOLD until Paper Publication Authors: Scalone, E., Boni, F., Milani, M., Mastrangelo, E., de Rosa, M. Description: Calcium-bound gelsoli...)
Current revision (12:09, 24 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6qw3 is ON HOLD until Paper Publication
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==Calcium-bound gelsolin domain 2==
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<StructureSection load='6qw3' size='340' side='right'caption='[[6qw3]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QW3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qw3 OCA], [https://pdbe.org/6qw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qw3 RCSB], [https://www.ebi.ac.uk/pdbsum/6qw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qw3 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[https://omim.org/entry/105120 105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The second domain of gelsolin (G2) hosts mutations responsible for a hereditary form of amyloidosis. The active form of gelsolin is Ca(2+)-bound; it is also a dynamic protein, hence structural biologists often rely on the study of the isolated G2. However, the wild type G2 structure that have been used so far in comparative studies is bound to a crystallographic Cd(2+), in lieu of the physiological calcium. Here, we report the wild type structure of G2 in complex with Ca(2+) highlighting subtle ion-dependent differences. Previous findings on different G2 mutations are also briefly revised in light of these results.
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Authors: Scalone, E., Boni, F., Milani, M., Mastrangelo, E., de Rosa, M.
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High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion.,Bollati M, Scalone E, Boni F, Mastrangelo E, Giorgino T, Milani M, de Rosa M Biochem Biophys Res Commun. 2019 Aug 12. pii: S0006-291X(19)31515-3. doi:, 10.1016/j.bbrc.2019.08.013. PMID:31416615<ref>PMID:31416615</ref>
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Description: Calcium-bound gelsolin domain 2
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Milani, M]]
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<div class="pdbe-citations 6qw3" style="background-color:#fffaf0;"></div>
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[[Category: Scalone, E]]
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[[Category: Boni, F]]
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==See Also==
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[[Category: Mastrangelo, E]]
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*[[Gelsolin 3D structures|Gelsolin 3D structures]]
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[[Category: De Rosa, M]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Boni F]]
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[[Category: Mastrangelo E]]
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[[Category: Milani M]]
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[[Category: Scalone E]]
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[[Category: De Rosa M]]

Current revision

Calcium-bound gelsolin domain 2

PDB ID 6qw3

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