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Aminopeptidase 3D structures

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== 3D Structures of Aminopeptidase ==
+
== 3D Structures of [[Aminopeptidase]] ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*Cysteine aminopeptidase
*Cysteine aminopeptidase
-
**[[3pw3]] – PdCys-AP – Parabacteroides distasonis<br />
+
**[[3pw3]] – PdCys-AP – ''Parabacteroides distasonis''<br />
-
*Glutamic acid aminopeptidase
+
*Glutamyl aminopeptidase or aminopeptidase A
**[[4kx7]] – hGlu-AP + Zn – human<br />
**[[4kx7]] – hGlu-AP + Zn – human<br />
**[[4kx8]], [[4kxb]] – hGlu-AP + Zn + statin derivative<br />
**[[4kx8]], [[4kxb]] – hGlu-AP + Zn + statin derivative<br />
**[[4kx9]], [[4kxa]], [[4kxc]], [[4kxd]] – hGlu-AP + Zn + amino acid<br />
**[[4kx9]], [[4kxa]], [[4kxc]], [[4kxd]] – hGlu-AP + Zn + amino acid<br />
-
**[[2wyr]] – PhGlu-AP+Co – Pyrococcus horikoshii<br />
+
**[[2wyr]] – PhGlu-AP+Co – ''Pyrococcus horikoshii''<br />
-
**[[3kl9]] – SpGlu-AP – Streptococcus pneumonia<br />
+
**[[3kl9]] – SpGlu-AP – ''Streptococcus pneumonia''<br />
*Alanine aminopeptidase or aminopeptidase N or a-aminoacylpeptide hydrolase
*Alanine aminopeptidase or aminopeptidase N or a-aminoacylpeptide hydrolase
-
**[[2hpo]], [[2dq6]], [[3puu]], [[6g8b]] – EcAPN - Escherichia coli<br />
+
**[[2hpo]], [[2dq6]], [[3puu]], [[6g8b]] – EcAPN - ''Escherichia coli''<br />
-
**[[2gtq]] – NmAPN – Neisseria meningitides<br />
+
**[[2gtq]] – NmAPN – ''Neisseria meningitides''<br />
-
**[[5dll]] – FtAPN - Francisella tularensis<br />
+
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
-
**[[3ebg]] – PfAla-AP - Plasmodium falciparum<br />
+
**[[3ebg]] – PfAla-AP - ''Plasmodium falciparum''<br />
 +
**[[6oiu]] – APN – ''Toxoplasma gondii''<br />
*Alanine aminopeptidase binary complex
*Alanine aminopeptidase binary complex
**[[4fyq]], [[5lhd]] - hAla-AP + Zn<br />
**[[4fyq]], [[5lhd]] - hAla-AP + Zn<br />
 +
**[[6u7e]], [[6u7f]], [[6u7g]], [[7vpp]], [[7vpq]] – hAPN + spike glycoprotein<br />
 +
**[[6xwd]], [[7aew]] – hAPN + 14-3-3 protein sigma<br />
**[[4fke]], [[5lds]], [[5lg6]], [[5z65]] – pAla-AP + Zn – pig<br />
**[[4fke]], [[5lds]], [[5lg6]], [[5z65]] – pAla-AP + Zn – pig<br />
 +
**[[7u0l]] – dAPN + spike glycoprotein - dog<br />
**[[3ked]] – EcAPN+2,4-diaminobutyric acid <br />
**[[3ked]] – EcAPN+2,4-diaminobutyric acid <br />
**[[2hpt]], [[2dqm]] – EcAPN+bestatin<br />
**[[2hpt]], [[2dqm]] – EcAPN+bestatin<br />
Line 37: Line 41:
**[[4pw4]] – NmAP N + Phe analog <br />
**[[4pw4]] – NmAP N + Phe analog <br />
**[[4qhp]], [[4qir]], [[4qme]], [[4qpe]], [[4quo]] – NmAP N + dipeptide analog <br />
**[[4qhp]], [[4qir]], [[4qme]], [[4qpe]], [[4quo]] – NmAP N + dipeptide analog <br />
-
**[[4fgm]] – APN + Zn – Idiomarina loihiensis<br />
+
**[[4fgm]] – APN + Zn – ''Idiomarina loihiensis''<br />
-
**[[5zi5]] – LpAPN + Zn – Legionella pneumophila<br />
+
**[[5zi5]] – LpAPN + Zn – ''Legionella pneumophila''<br />
**[[5zi7]] – LpAPN + Glu<br />
**[[5zi7]] – LpAPN + Glu<br />
**[[5zie]] – LpAPN + Asp<br />
**[[5zie]] – LpAPN + Asp<br />
 +
**[[7v9n]], [[7v9o]], [[7v9p]], [[7v9q]] – APN + Zn – ''Saccharopolyspora erythrea''<br />
*Alanine aminopeptidase ternary complex
*Alanine aminopeptidase ternary complex
Line 47: Line 52:
**[[4fys]] - hAla-AP + Zn + angiotensin<br />
**[[4fys]] - hAla-AP + Zn + angiotensin<br />
**[[4fyt]] - hAla-AP + Zn + amastatin<br />
**[[4fyt]] - hAla-AP + Zn + amastatin<br />
-
**[[6atk]] – hAPN+ Zn + spike glycoprotein<br />
 
**[[4fkh]] – pAla-AP + Zn + Ala<br />
**[[4fkh]] – pAla-AP + Zn + Ala<br />
**[[6buy]], [[6bv0]], [[6bv1]], [[6bv2]], [[6bv3]], [[6bv4]] – pAPN+ Zn + amino acid<br />
**[[6buy]], [[6bv0]], [[6bv1]], [[6bv2]], [[6bv3]], [[6bv4]] – pAPN+ Zn + amino acid<br />
Line 64: Line 68:
*Aminopeptidase B
*Aminopeptidase B
-
**[[6cxd]] – YpAPB – Yersinia pestis<br />
+
**[[6cxd]] – YpAPB – ''Yersinia pestis''<br />
 +
**[[6oad]], [[6ov8]] – EcAPB + Zn <br />
*Aminopeptidase C see [[Dipeptidyl aminopeptidase]]
*Aminopeptidase C see [[Dipeptidyl aminopeptidase]]
-
*Aminopeptidase P
+
*Proline aminopeptidase or X-Pro aminopeptidase or aminopeptidase P or X-prolyl aminopeptidase or Xaa-Pro dipeptidase
-
 
+
-
**[[5wze]] – PaAPP + Ala + Pro – Pseudomonas aeruginosa<br />
+
-
 
+
-
*Proline aminopeptidase
+
**[[3ctz]] – X hPro-AP<br />
**[[3ctz]] – X hPro-AP<br />
**[[1wlr]] - Xaa EcPro-AP<br />
**[[1wlr]] - Xaa EcPro-AP<br />
**[[2bws]], [[2bwt]], [[2bwu]], [[2bwv]], [[2bww]], [[2bwx]], [[2bwy]] - Xaa EcPro-AP (mutant) <br />
**[[2bws]], [[2bwt]], [[2bwu]], [[2bwv]], [[2bww]], [[2bwx]], [[2bwy]] - Xaa EcPro-AP (mutant) <br />
-
**[[3ovk]] – Xaa Pro-AP – Streptococcus pyogenes<br />
+
**[[3ovk]] – Xaa Pro-AP – ''Streptococcus pyogenes''<br />
-
**[[3il0]] - Xaa Pro-AP – Streptococcus thermophilus<br />
+
**[[3il0]] - Xaa Pro-AP – ''Streptococcus thermophilus''<br />
-
**[[2zsg]] – X TmPro-AP – Thermatoga maritima<br />
+
**[[2zsg]] – X TmPro-AP – ''Thermatoga maritima''<br />
-
**[[1qtr]] – SmPro-AP – Serratia marcescens<br />
+
**[[1qtr]] – SmPro-AP – ''Serratia marcescens''<br />
-
**[[1xqv]] – TaPro-AP (mutant) – Thermoplasma acidophilum<br />
+
**[[1xqv]] – TaPro-AP (mutant) – ''Thermoplasma acidophilum''<br />
-
**[[3azo]] – SmoPro-AP – Streptomyces morookaensis<br />
+
**[[3azo]] – SmoPro-AP – ''Streptomyces morookaensis''<br />
**[[3azp]] - SmoPro-AP (mutant) <br />
**[[3azp]] - SmoPro-AP (mutant) <br />
Line 93: Line 94:
**[[1w2m]] - Xaa EcPro-AP+Ca<br />
**[[1w2m]] - Xaa EcPro-AP+Ca<br />
**[[1n51]] – Xaa EcPro-AP+apstatin<br />
**[[1n51]] – Xaa EcPro-AP+apstatin<br />
-
**[[3ig4]] – Xaa Pro-AP + Mn – Bacillus anthracis<br />
+
**[[3ig4]] – Xaa Pro-AP + Mn – ''Bacillus anthracis''<br />
-
**[[4fkc]] – Xaa TsPro-AP + Cd – Thermococcus sibiricus <br />
+
**[[4fkc]] – Xaa TsPro-AP + Cd – ''Thermococcus sibiricus'' <br />
**[[4rgz]] – Xaa TsPro-AP + Zn<br />
**[[4rgz]] – Xaa TsPro-AP + Zn<br />
**[[4pv4]] – YpPro-AP II + Mg <br />
**[[4pv4]] – YpPro-AP II + Mg <br />
Line 100: Line 101:
**[[1xqw]], [[1xqx]], [[1xqy]], [[1xrl]], [[1xrm]], [[1xrn]], [[1xro]], [[1xrp]], [[1xrq]], [[1xrr]] – TaPro-AP+polypeptide<br />
**[[1xqw]], [[1xqx]], [[1xqy]], [[1xrl]], [[1xrm]], [[1xrn]], [[1xro]], [[1xrp]], [[1xrq]], [[1xrr]] – TaPro-AP+polypeptide<br />
**[[3azq]] - SmoPro-AP (mutant) + PGG<br />
**[[3azq]] - SmoPro-AP (mutant) + PGG<br />
 +
**[[7e5c]] - Pro-AP (mutant) + Mn – ''Pseudoalteromonas lipolytica''<br />
*Proline aminopeptidase higher complex
*Proline aminopeptidase higher complex
Line 109: Line 111:
**[[1wbq]], [[2bhb]] - Xaa EcPro-AP+Zn+Mg<br />
**[[1wbq]], [[2bhb]] - Xaa EcPro-AP+Zn+Mg<br />
**[[2bhc]] - Xaa EcPro-AP+Na+Mg<br />
**[[2bhc]] - Xaa EcPro-AP+Na+Mg<br />
-
**[[4s2r]] – CePro-AP 1 + Zn - Caenorhabditis elegans <br />
+
**[[4s2r]] – CePro-AP 1 + Zn - ''Caenorhabditis elegans'' <br />
**[[4s2t]] – CePro-AP 1 + Zn + apstatin <br />
**[[4s2t]] – CePro-AP 1 + Zn + apstatin <br />
 +
**[[5wze]] – PaAPP + Ala + Pro – ''Pseudomonas aeruginosa''<br />
*Leucine aminopeptidase
*Leucine aminopeptidase
**[[3qnf]] – hLeu-AP 1<br />
**[[3qnf]] – hLeu-AP 1<br />
-
**[[2xdt]], [[2yd0]] – hLeu-AP 1 soluble domain<br />
+
**[[2yd0]] – hLeu-AP 1 soluble domain<br />
**[[3rjo]] - hLeu-AP 1 peptide-binding domain<br />
**[[3rjo]] - hLeu-AP 1 peptide-binding domain<br />
**[[1lam]], [[1lap]] – bLue-AP – bovine<br />
**[[1lam]], [[1lap]] – bLue-AP – bovine<br />
Line 121: Line 124:
**[[5jhc]] – yLeu-AP 1 (mutant) <br />
**[[5jhc]] – yLeu-AP 1 (mutant) <br />
**[[1gyt]] – EcLeu-AP<br />
**[[1gyt]] – EcLeu-AP<br />
-
**[[3jru]] – Leu-AP – Xanthomonas oryzae<br />
+
**[[3jru]] – Leu-AP – ''Xanthomonas oryzae''<br />
**[[2hc9]], [[2hb6]]– CeLeu-AP <br />
**[[2hc9]], [[2hb6]]– CeLeu-AP <br />
-
**[[3h8e]], [[3h8f]], [[3h8g]] – Leu-AP – Pseudomonas putida<br />
+
**[[3h8e]], [[3h8f]], [[3h8g]] – Leu-AP – ''Pseudomonas putida''<br />
**[[3kqx]], [[3kqz]], [[3kr4]], [[3kr5]] – PfLeu-AP <br />
**[[3kqx]], [[3kqz]], [[3kr4]], [[3kr5]] – PfLeu-AP <br />
-
**[[3fh4]], [[1rtq]], [[2dea]]– VpLeu-AP – Vibrio proteolyticus<br />
+
**[[3fh4]], [[1rtq]], [[2dea]] – VpLeu-AP – ''Vibrio proteolyticus''<br />
**[[3b35]], [[3b3t]], [[3b3v]], [[2anp]] - VpLeu-AP (mutant) <br />
**[[3b35]], [[3b3t]], [[3b3v]], [[2anp]] - VpLeu-AP (mutant) <br />
-
**[[5lhj]] – StrLeu-AP 2 – Streptomyces<br />
+
**[[5lhj]] – StrLeu-AP 2 – ''Streptomyces''<br />
-
**[[5ntg]], [[5ntf]] – Leu-AP – Trypanosoma cruzi<br />
+
**[[5ntg]], [[5ntf]] – Leu-AP – ''Trypanosoma cruzi''<br />
*Leucine aminopeptidase binary complex
*Leucine aminopeptidase binary complex
Line 148: Line 151:
**[[2prq]] – VpLeu-AP+Co<br />
**[[2prq]] – VpLeu-AP+Co<br />
**[[1xry]], [[1txr]] – VpLeu-AP+bestatin<br />
**[[1xry]], [[1txr]] – VpLeu-AP+bestatin<br />
-
**[[3tc8]] - PdLeu-AP + Zn<br />
+
**[[3tc8]] - PdLeu-AP + Zn - ''Parabacteroides distasonis'' <br />
-
**[[4fuu]] - Leu-AP + Zn – Bacterioides thetaiotaomicron<br />
+
**[[4fuu]] - BtLeu-AP + Zn – ''Bacterioides thetaiotaomicron''<br />
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
-
**[[4zla]], [[4zi6]] – Leu-AP + Zn – Helicobacter pylori <br />
+
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
**[[5gne]], [[6esl]] – LpLeu-AP + Zn <br />
**[[5gne]], [[6esl]] – LpLeu-AP + Zn <br />
-
**[[6f3k]] – PhLeu-AP + Zn <br />
+
**[[6f3k]], [[6r8n]] – PhLeu-AP + Zn <br />
 +
**[[6wvv]] – PvLeu-AP M17 + Zn – ''Plasmodium vivax''<br />
 +
**[[7k5k]] – PvLeu-AP M17 + Mn<br />
 +
**[[7srv]] – PfLeu-AP + Zn <br />
*Leucine aminopeptidase ternary complex
*Leucine aminopeptidase ternary complex
Line 161: Line 167:
**[[3t8w]], [[4k3n]], [[4r6t]], [[6eee]] – PfLeu-AP + Zn + inhibitor <br />
**[[3t8w]], [[4k3n]], [[4r6t]], [[6eee]] – PfLeu-AP + Zn + inhibitor <br />
**[[4r76]], [[4r7m]], [[4x2t]] – PfLeu-AP (mutant) + Zn + inhibitor <br />
**[[4r76]], [[4r7m]], [[4x2t]] – PfLeu-AP (mutant) + Zn + inhibitor <br />
-
**[[5ntd]] – TbLeu-AP + Mn + bestatin – Trypanosoma brucei<br />
+
**[[5ntd]] – TbLeu-AP + Mn + bestatin – ''Trypanosoma brucei''<br />
 +
**[[6ee2]], [[6eee]] - PfLue-AP M17 +Zn + inhibitor<br />
 +
**[[7oez]] – AoLeu-AP + Zn + Leu – ''Aspergillus oryzae''<br />
 +
**[[7d1e]] - BtLeu-AP + Zn + acetylhistamine<br />
*Leucine-cysteine aminopeptidase
*Leucine-cysteine aminopeptidase
Line 167: Line 176:
**[[4p8q]], [[5c97]], [[5mj6]] – hLeu-Cys-AP + Zn<br />
**[[4p8q]], [[5c97]], [[5mj6]] – hLeu-Cys-AP + Zn<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
-
**[[4z7i]] – hLeu-Cys-AP + Zn + peptide<br />
+
**[[4z7i]], [[6ydx]] – hLeu-Cys-AP + Zn + peptide<br />
 +
**[[7zyf]] – hLeu-Cys-AP + Zn + inhibitor<br />
*Lysine aminopeptidase
*Lysine aminopeptidase
Line 176: Line 186:
**[[2gtx]], [[2gu7]] – EcMet-AP<br />
**[[2gtx]], [[2gu7]] – EcMet-AP<br />
-
**[[3fm3]] – EncMet-AP – Encephalitozoon cuniculi<br />
+
**[[6iz7]] – EcMet-AP (mutant) – Cryo EM<br />
-
**[[3tb5]] – Met-AP – Enterococcus faecalis<br />
+
**[[3fm3]] – EncMet-AP – ''Encephalitozoon cuniculi''<br />
 +
**[[3tb5]] – Met-AP – ''Enterococcus faecalis''<br />
**[[1o0x]] – TmMet-AP<br />
**[[1o0x]] – TmMet-AP<br />
**[[4km3]] – SpMet-AP<br />
**[[4km3]] – SpMet-AP<br />
-
**[[4km3]] – Met-AP – Acinetobacter baumannii<br />
+
**[[4km3]], [[6mrf]] – Met-AP – ''Acinetobacter baumannii''<br />
 +
**[[6k26]] – VcMet-AP – ''Vibrio cholerae''<br />
 +
**[[6lvh]] – PyfMet-AP – ''Pyrococcus furiosus''<br />
*Methionine aminopeptidase binary complex
*Methionine aminopeptidase binary complex
-
**[[3mr1]], [[3mx6]] – Met-AP+Mn – Rickettsia prowazekii<br />
+
**[[3mr1]], [[3mx6]] – Met-AP+Mn – ''Rickettsia prowazekii''<br />
-
**[[2dfi]], [[1xgm]], [[1xgn]], [[1xgo]], [[1xgs]] – PyfMet-AP+Co – Pyrococcus furiosus<br />
+
**[[2dfi]], [[1xgm]], [[1xgn]], [[1xgo]], [[1xgs]], [[6m00]] – PyfMet-AP+Co <br />
**[[1wkm]] - PyfMet-AP+Mn<br />
**[[1wkm]] - PyfMet-AP+Mn<br />
**[[4fo7]], [[4juq]] - PaMet-AP+Mn <br />
**[[4fo7]], [[4juq]] - PaMet-AP+Mn <br />
**[[4fo8]] - PaMet-AP+Mn + Met <br />
**[[4fo8]] - PaMet-AP+Mn + Met <br />
-
**[[1yj3]], [[3ror]], [[4ook]] - MtMet-AP 2 +Co<br />
+
**[[1yj3]], [[3ror]], [[4ook]] - MtMet-AP 2 + Co - ''Mycobacterium tuberculosis''<br />
**[[5ypj]] – MtMet-AP (mutant) + Co <br />
**[[5ypj]] – MtMet-AP (mutant) + Co <br />
**[[3pka]] - MtMet-AP+Mn<br />
**[[3pka]] - MtMet-AP+Mn<br />
**[[3pkb]], [[3pkc]], [[3pkd]], [[3pke]] - MtMet-AP+bengamide inhibitor<br />
**[[3pkb]], [[3pkc]], [[3pkd]], [[3pke]] - MtMet-AP+bengamide inhibitor<br />
**[[1y1n]] - MtMet-AP+K<br />
**[[1y1n]] - MtMet-AP+K<br />
-
**[[3tav]] – Met-AP + Mg – Mycobacterium abscessus<br />
+
**[[3tav]] – Met-AP + Mg – ''Mycobacterium abscessus''<br />
**[[3fmq]], [[3fmr]]- EncMet-AP+angiogenesis inhibitor<br />
**[[3fmq]], [[3fmr]]- EncMet-AP+angiogenesis inhibitor<br />
**[[1mat]] – EcMet-AP+Co<br />
**[[1mat]] – EcMet-AP+Co<br />
-
**[[2mat]], [[4mat]], [[4u76]], [[4u75]], [[4u73]], [[4u71]], [[4u70]], [[4u6z]], [[4u6w]], [[4u6j]], [[4u6e]], [[4u6c]], [[4u69], [[4u1b]] - EcMet-AP 1 (mutant)+Co<br />
+
**[[2mat]], [[4mat]], [[4u76]], [[4u75]], [[4u73]], [[4u71]], [[4u70]], [[4u6z]], [[4u6w]], [[4u6j]], [[4u6e]], [[4u6c]], [[4u69]], [[4u1b]] - EcMet-AP 1 (mutant)+Co<br />
 +
**[[6izi]] - EcMet-AP 1 (mutant)+ peptide deformylase – Cryo EM<br />
 +
**[[6j0a]] - EcMet-AP 1 + trigger factor – Cryo EM<br />
**[[3s6b]] – PfMet-AP + Fe <br />
**[[3s6b]] – PfMet-AP + Fe <br />
**[[4fuk]] – TbMet-AP + Zn<br />
**[[4fuk]] – TbMet-AP + Zn<br />
 +
**[[6ksg]], [[6lh7]] – VcMet-AP + Ni<br />
*Methionine aminopeptidase ternary complex
*Methionine aminopeptidase ternary complex
-
**[[3iu7]] – MtMet-AP+Mn +A02 – Mycobacterium tuberculosis<br />
+
**[[3iu7]] – MtMet-AP+Mn +A02<br />
**[[3iu8]], [[3iu9]] - MtMet-AP+Ni + inhibitor<br />
**[[3iu8]], [[3iu9]] - MtMet-AP+Ni + inhibitor<br />
**[[4idy]], [[4iec]] - MtMet-AP+K + hydroxyethyl disulfide<br />
**[[4idy]], [[4iec]] - MtMet-AP+K + hydroxyethyl disulfide<br />
**[[4if7]] - MtMet-AP+K + homocysteinemethyl disulfide<br />
**[[4if7]] - MtMet-AP+K + homocysteinemethyl disulfide<br />
-
**[[5ypd]], [[5yoh]], [[5yoi]] – MtMet-AP (mutant) + Co + Met<br />
+
**[[5ypd]], [[5yoh]], [[5yoi]], [[5yxf]] – MtMet-AP (mutant) + Co + Met<br />
-
**[[3d27]], [[2q92]], [[2q93]], [[2q94]], [[2q95]], [[2q96]] ,[[2p98]] [[2p99]], [[2p9a]], [[2gu4]], [[2gu5]], [[2gu6]], [[2evc]], [[2evm]], [[2evo]], [[2bbv]], [[1xnz, [[4a6v]], [[4a6w]], [[2bb7]] – EcMet-AP+Mn+inhibitor<br />
+
**[[3d27]], [[2q92]], [[2q93]], [[2q94]], [[2q95]], [[2q96]] ,[[2p98]] [[2p99]], [[2p9a]], [[2gu4]], [[2gu5]], [[2gu6]], [[2evc]], [[2evm]], [[2evo]], [[2bbv]], [[1xnz]], [[4a6v]], [[4a6w]], [[2bb7]] – EcMet-AP+Mn+inhibitor<br />
**[[2gg0]], [[2gg2]], [[2gg3]], [[2gg5]], [[2gg7]], [[2gg8]], [[2gg9]], [[2ggb]], [[2ggc]], [[4pnc]] - EcMet-AP+Co+inhibitor<br />
**[[2gg0]], [[2gg2]], [[2gg3]], [[2gg5]], [[2gg7]], [[2gg8]], [[2gg9]], [[2ggb]], [[2ggc]], [[4pnc]] - EcMet-AP+Co+inhibitor<br />
**[[1c21]], [[1c22]], [[1c23]], [[1c24]] - EcMet-AP +Co + methionine derivative<br />
**[[1c21]], [[1c22]], [[1c23]], [[1c24]] - EcMet-AP +Co + methionine derivative<br />
Line 214: Line 230:
**[[1yvm]] – EcMet-AP (mutant)+Co+thiabendazole<br />
**[[1yvm]] – EcMet-AP (mutant)+Co+thiabendazole<br />
**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br />
**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br />
-
**[[1qxw]], [[1qxy]], [[1qxz]] – Met-AP+Co+inhibitor - Staphylococcus aureus<br />
 
- 
*Human methionine aminopeptidase
*Human methionine aminopeptidase
**[[2b3h]], [[2b3k]] - hMet-AP 1 + Co<br />
**[[2b3h]], [[2b3k]] - hMet-AP 1 + Co<br />
**[[5yr7]] – hMet-AP 1 (mutant) + Co<br />
**[[5yr7]] – hMet-AP 1 (mutant) + Co<br />
-
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]], [[4hxx]], [[4iu6]] – hMet-AP 1 + Co + inhibitor<br />
+
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]], [[4hxx]], [[4iu6]], [[6lzb]], [[6lzc]] –, hMet-AP 1 + Co + inhibitor<br />
-
**[[4fli]], [[4flj]], [[4flk]], [[4fll]], [[2nq6]], [[2nq7]], [[1yw7]], [[1yw8]], [[1yw9]] - hMet-AP 1 + Mn +inhibitor<br />
+
**[[4fli]], [[4flj]], [[4flk]], [[4fll]], [[2nq6]], [[2nq7]], [[1yw7]], [[1yw8]], [[1yw9]], [[7a12]], [[7a13]], [[7a14]], [[7a15]], [[7a16]] - hMet-AP 1 + Mn +inhibitor<br />
**[[2g6p]] - hMet-AP 1 truncated+Mn+inhibitor<br />
**[[2g6p]] - hMet-AP 1 truncated+Mn+inhibitor<br />
**[[5yr4]], [[5yr6]] – hMet-AP 1 (mutant) + TNP470 + Co<br />
**[[5yr4]], [[5yr6]] – hMet-AP 1 (mutant) + TNP470 + Co<br />
Line 230: Line 244:
**[[1qzy]], [[1b59]], [[1b6a]], [[1bn5]], [[2oaz]], [[5d6f]], [[5d6e]], [[5cls]] - hMet-AP 2 +Co+inhibitor<br />
**[[1qzy]], [[1b59]], [[1b6a]], [[1bn5]], [[2oaz]], [[5d6f]], [[5d6e]], [[5cls]] - hMet-AP 2 +Co+inhibitor<br />
**[[2adu]] - hMet-AP 2 (mutant) +Co+inhibitor<br />
**[[2adu]] - hMet-AP 2 (mutant) +Co+inhibitor<br />
 +
**[[6qed]], [[6qef]], [[6qeg]], [[6qei]], [[6qej]], [[6qeh]]- hMet-AP 2 + Zn + inhibitor<br />
**[[5lyw]], [[5lyx]] - hMet-AP 2 (mutant) + Zn + inhibitor<br />
**[[5lyw]], [[5lyx]] - hMet-AP 2 (mutant) + Zn + inhibitor<br />
**[[1r58]], [[1r5g]], [[1r5h]], [[5ji6]], [[5jhu]], [[5jfr]], [[5cls]], [[4z7m]], [[5jhu]], [[5jfr]], [[2ea2]], [[2ea4]], [[2ga2]], [[5lyw]] - hMet-AP 2 +Mn+inhibitor<br />
**[[1r58]], [[1r5g]], [[1r5h]], [[5ji6]], [[5jhu]], [[5jfr]], [[5cls]], [[4z7m]], [[5jhu]], [[5jfr]], [[2ea2]], [[2ea4]], [[2ga2]], [[5lyw]] - hMet-AP 2 +Mn+inhibitor<br />
Line 238: Line 253:
**[[4jbs]] – hArg-AP 2 + Zn + inhibitor<br />
**[[4jbs]] – hArg-AP 2 + Zn + inhibitor<br />
**[[5ab2]], [[5ab0]] – hArg-AP 2 + Zn + peptide<br />
**[[5ab2]], [[5ab0]] – hArg-AP 2 + Zn + peptide<br />
 +
**[[6hc6]], [[6hc7]] – Arg-AP + Zn – ''Bacillus subtilis''<br />
*Aspartic acid aminopeptidase
*Aspartic acid aminopeptidase
Line 243: Line 259:
**[[4dyo]] – hAsp-AP+aspartic hydroxamate<br />
**[[4dyo]] – hAsp-AP+aspartic hydroxamate<br />
**[[3var]], [[3vat]] – bAsp-AP<br />
**[[3var]], [[3vat]] – bAsp-AP<br />
-
**[[4eme]] – PfAsp-AP + Zn<br />
+
**[[4eme]], [[6pev]] – PfAsp-AP + Zn<br />
*Asparagine aminopeptidase
*Asparagine aminopeptidase
Line 249: Line 265:
**[[3c17]], [[2zak]] – EcAsn-AP (mutant) <br />
**[[3c17]], [[2zak]] – EcAsn-AP (mutant) <br />
**[[2zal]] – EcAsn-AP+Asp<br />
**[[2zal]] – EcAsn-AP+Asp<br />
-
**[[2gez]] – Asn-AP – Lupinus luteus<br />
+
**[[2gez]] – Asn-AP – ''Lupinus luteus''<br />
*Serine aminopeptidase
*Serine aminopeptidase
-
**[[1b65]] – OaSer-AP – Ochrobactrum anthropi<br />
+
**[[1b65]] – OaSer-AP – ''Ochrobactrum anthropi''<br />
*Cytosolic aminopeptidase
*Cytosolic aminopeptidase
**[[3pei]] – FtCyt-AP <br />
**[[3pei]] – FtCyt-AP <br />
-
**[[3kzw]] – Cyt-AP – Staphylococcus aureus<br />
+
**[[3ij3]] – Cyt-AP – ''Coxiella burnetii''<br />
-
**[[3ij3]] – Cyt-AP – Coxiella burnetii<br />
+
-
*Endoplasmic reticulum aminopeptidase
+
*Endoplasmic reticulum aminopeptidase or ERAP1 or ERAP2
-
**[[5j5e]] – hARTS-1 ERAP1 domain<br />
+
**[[3qnf]] – hARTS-1<br />
-
**[[3se6]] – hARTS-2<br />
+
**[[3rjo]], [[5j5e]] – hARTS-1 ERAP1 domain 530-941<br />
-
**[[4e36]] – hARTS-2 + Zn<br />
+
**[[2yd0]] – hARTS-1 soluble domain 46-940<br />
-
**[[5k1v]], [[5j6s]] – hARTS-2 + Zn + inhibitor<br />
+
**[[6mgq]], [[6q4r]], [[6rqx]], [[6ryf]] – hARTS-1 + phosphinic inhibitor<br />
 +
**[[7mwc]] – hARTS-1 + peptide<br />
 +
**[[3mdj]], [[6m8p]], [[6mgq]] – hARTS-1 + Zn + inhibitor<br />
 +
**[[6t6r]] – hARTS-1 (mutant) + Zn + inhibitor<br />
 +
**[[3se6]], [[5cu5]] – hARTS-2<br />
 +
**[[4e36]] – hARTS-2 (mutant) + Zn<br />
 +
**[[4jbs]], [[5k1v]], [[5j6s]], [[6ea4]], [[7nsk]], [[7nup]], [[7p7p]], [[7pfs]], [[7sh0]], [[7z28]] – hARTS-2 + Zn + inhibitor<br />
 +
**[[5ab2]], [[5ab0]] – hARTS-2 + Zn + peptide<br />
*Non-specific aminopeptidase
*Non-specific aminopeptidase
-
**[[2ek8]] – AnAP – Aneurinibacillus<br />
+
**[[2ek8]] – AnAP – ''Aneurinibacillus''<br />
**[[2ek9]] – AnAP+bestatin<br />
**[[2ek9]] – AnAP+bestatin<br />
**[[1y0r]], [[1xfo]] – PhAP<br />
**[[1y0r]], [[1xfo]] – PhAP<br />
Line 281: Line 303:
**[[4icr]] – SpAP Peps (mutant) + Zn<br />
**[[4icr]] – SpAP Peps (mutant) + Zn<br />
**[[4ics]] – SpAP Peps (mutant) + Zn + Trp + Gly<br />
**[[4ics]] – SpAP Peps (mutant) + Zn + Trp + Gly<br />
-
**[[4wwv]] – AP M42 – Desulfuroccus kamchatkensis<br />
+
**[[4wwv]] – AP M42 – ''Desulfuroccus kamchatkensis''<br />
-
**[[4p6y]] – TmAP M42 <br />
+
**[[4p6y]], [[6nw5]] – TmAP <br />
 +
**[[6ica]] – LpAP + Zn<br />
*Cold-activated aminopeptidase
*Cold-activated aminopeptidase
-
**[[3cia]] – Col-AP – Colwellia psychrerythraea<br />
+
**[[3cia]] – Col-AP – ''Colwellia psychrerythraea''<br />
*Deblocking aminopeptidase
*Deblocking aminopeptidase
-
**[[2gre]] – DAP – Bacillus cereus<br />
+
**[[2gre]] – DAP – ''Bacillus cereus''<br />
*Heat stable aminopeptidase
*Heat stable aminopeptidase
-
**[[2ayi]] – AmpT – Thermus thermophilus<br />
+
**[[2ayi]] – AmpT – ''Thermus thermophilus''<br />
-
*Aminopeptidase from Staphylococcus aureus
+
*Aminopeptidase from ''Staphylococcus aureus''
-
**[[1zjc]] - AmpS<br />
+
**[[1zjc]] - SaAmpS<br />
 +
**[[1qxw]], [[1qxy]], [[1qxz]] – SaMet-AP+Co+inhibitor <br />
 +
**[[3kzw]] – SaCyt-AP<br />
-
*Stereomyces griesus aminopeptidase
+
*''Stereomyces griesus'' aminopeptidase
**[[1xjo]], [[1cp7]] - SGAP <br />
**[[1xjo]], [[1cp7]] - SGAP <br />
-
**[[1qq9]], [[1f2o]], [[1f2p]], [[1tf8]], [[1tf9]], [[1tkf]], [[1tkh]], [[1tkj, [[1xbu]]] - SGAP + amino acid <br />
+
**[[1qq9]], [[1f2o]], [[1f2p]], [[1tf8]], [[1tf9]], [[1tkf]], [[1tkh]], [[1tkj]], [[1xbu]]] - SGAP + amino acid <br />
*Metalloaminopeptidase
*Metalloaminopeptidase
Line 309: Line 334:
**[[3q43]], [[3q44]] – PfPFAP (mutant) + bestatin derivative<br />
**[[3q43]], [[3q44]] – PfPFAP (mutant) + bestatin derivative<br />
-
*-peptidyl AP
+
*β-peptidyl AP
-
**[[3n2w]] – SxBapA – Sphingosinicella xenopeptidilytica<br />
+
**[[3n2w]] – SxBapA – ''Sphingosinicella xenopeptidilytica''<br />
**[[3n5i]] – SxBapA (mutant) <br />
**[[3n5i]] – SxBapA (mutant) <br />
**[[3n33]] – SxBapA + AEBSF<br />
**[[3n33]] – SxBapA + AEBSF<br />
**[[3ndv]], [[3nfb]] – SxBapA + ampicillin<br />
**[[3ndv]], [[3nfb]] – SxBapA + ampicillin<br />
-
**[[5tzb]] - AP – Burkholderia<br />
+
**[[5tzb]] - AP – ''Burkholderia''<br />
*M1 family AP
*M1 family AP
Line 326: Line 351:
**[[5xm7]], [[5y19]], [[5y1h]], [[5y1k]], [[5y1q]], [[5y1r]], [[5y1s]], [[5y1t]], [[5y1v]], [[5y3i]] - PfLeu-AP + Zn + Mg + inhibitor<br />
**[[5xm7]], [[5y19]], [[5y1h]], [[5y1k]], [[5y1q]], [[5y1r]], [[5y1s]], [[5y1t]], [[5y1v]], [[5y3i]] - PfLeu-AP + Zn + Mg + inhibitor<br />
**[[4zx6]], [[4zx5]], [[4zx4]], [[4zx5]], [[4zx3]], [[4zw8]], [[4zw7]], [[4zw6]], [[4zw5]], [[4zw3]], [[4zqt]], [[4x2u]], [[6ea1]], [[6ea2]], [[6eaa]], [[6eab]], [[6ee3]], [[6ee4]], [[6ee6]], [[6eed]] - PfLeu-AP (mutant) + Zn + Mg + inhibitor<br />
**[[4zx6]], [[4zx5]], [[4zx4]], [[4zx5]], [[4zx3]], [[4zw8]], [[4zw7]], [[4zw6]], [[4zw5]], [[4zw3]], [[4zqt]], [[4x2u]], [[6ea1]], [[6ea2]], [[6eaa]], [[6eab]], [[6ee3]], [[6ee4]], [[6ee6]], [[6eed]] - PfLeu-AP (mutant) + Zn + Mg + inhibitor<br />
 +
**[[6sbq]], [[6sbr]] - PfAla-AP + Zn + inhibitor<br />
 +
**[[3q43]], [[3q44]] – PfAP (mutant) + bestatin derivative<br />
}}
}}
Tripeptidyl aminotransferase see [[Tripeptidyl peptidase]]
Tripeptidyl aminotransferase see [[Tripeptidyl peptidase]]
Dipeptidyl aminotransferase see [[Dipeptidyl peptidase]]
Dipeptidyl aminotransferase see [[Dipeptidyl peptidase]]
 +
[[Category: Topic Page]]

Current revision

3D Structures of Aminopeptidase

Updated on 07-September-2022

Tripeptidyl aminotransferase see Tripeptidyl peptidase Dipeptidyl aminotransferase see Dipeptidyl peptidase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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