2chl

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[[Image:2chl.gif|left|200px]]<br />
 
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<applet load="2chl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2chl, resolution 1.95&Aring;" />
 
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'''STRUCTURE OF CASEIN KINASE 1 GAMMA 3'''<br />
 
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==About this Structure==
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==Structure of casein kinase 1 gamma 3==
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2CHL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and DKI as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CHL OCA].
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<StructureSection load='2chl' size='340' side='right'caption='[[2chl]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2chl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHL FirstGlance]. <br>
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[[Category: Arrowsmith, C.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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[[Category: Bunkoczi, G.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Das, S.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2chl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chl OCA], [https://pdbe.org/2chl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2chl RCSB], [https://www.ebi.ac.uk/pdbsum/2chl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2chl ProSAT]</span></td></tr>
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[[Category: Delft, F.Von.]]
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</table>
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[[Category: Edwards, A.]]
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== Function ==
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[[Category: Fedorov, O.]]
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[https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
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[[Category: Gileadi, O.]]
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== Evolutionary Conservation ==
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[[Category: Knapp, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Rellos, P.]]
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Check<jmol>
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[[Category: Salah, E.]]
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<jmolCheckbox>
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[[Category: Savitsky, P.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2chl_consurf.spt"</scriptWhenChecked>
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[[Category: Sundstrom, M.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Ugochukwu, E.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Weigelt, J.]]
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</jmolCheckbox>
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[[Category: DKI]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2chl ConSurf].
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[[Category: SO4]]
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<div style="clear:both"></div>
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[[Category: alternative splicing]]
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[[Category: atp-binding]]
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[[Category: kinase]]
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[[Category: nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: serine/threonine kinase]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: transferase]]
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[[Category: wnt signaling pathway]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 18:09:16 2007''
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==See Also==
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*[[Casein kinase 3D structures|Casein kinase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Bunkoczi G]]
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[[Category: Das S]]
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[[Category: Edwards A]]
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[[Category: Fedorov O]]
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[[Category: Gileadi O]]
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[[Category: Knapp S]]
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[[Category: Rellos P]]
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[[Category: Salah E]]
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[[Category: Savitsky P]]
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[[Category: Sundstrom M]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Structure of casein kinase 1 gamma 3

PDB ID 2chl

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OCA

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