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6mst
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==Cryo-EM structure of human AA amyloid fibril== | ==Cryo-EM structure of human AA amyloid fibril== | ||
| - | < | + | <SX load='6mst' size='340' side='right' viewer='molstar' caption='[[6mst]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6mst]] is a 12 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6mst]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MST FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mst OCA], [https://pdbe.org/6mst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mst RCSB], [https://www.ebi.ac.uk/pdbsum/6mst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mst ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Major acute phase reactant. Apolipoprotein of the HDL complex. |
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Fandrich | + | [[Category: Fandrich M]] |
| - | [[Category: Grigorieff | + | [[Category: Grigorieff N]] |
| - | [[Category: Liberta | + | [[Category: Liberta F]] |
| - | [[Category: Loerch | + | [[Category: Loerch S]] |
| - | [[Category: Rennegarbe | + | [[Category: Rennegarbe M]] |
| - | [[Category: Schmidt | + | [[Category: Schmidt M]] |
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Current revision
Cryo-EM structure of human AA amyloid fibril
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