This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4bw4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:06, 9 May 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='4bw4' size='340' side='right'caption='[[4bw4]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
<StructureSection load='4bw4' size='340' side='right'caption='[[4bw4]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4bw4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BW4 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4bw4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BW4 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9B6:7-(3,5-DIMETHYLISOXAZOL-4-YL)-8-METHOXY-1-(2-(TRIFLUOROMETHOXY)PHENYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-2(3H)-ONE'>9B6</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bw1|4bw1]], [[4bw2|4bw2]], [[4bw3|4bw3]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9B6:7-(3,5-DIMETHYLISOXAZOL-4-YL)-8-METHOXY-1-(2-(TRIFLUOROMETHOXY)PHENYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-2(3H)-ONE'>9B6</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bw4 OCA], [http://pdbe.org/4bw4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bw4 RCSB], [http://www.ebi.ac.uk/pdbsum/4bw4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bw4 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bw4 OCA], [https://pdbe.org/4bw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bw4 RCSB], [https://www.ebi.ac.uk/pdbsum/4bw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bw4 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 23:
==See Also==
==See Also==
-
*[[Bromodomain-containing protein|Bromodomain-containing protein]]
+
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Bamborough, P]]
+
[[Category: Bamborough P]]
-
[[Category: Bouillot, A]]
+
[[Category: Bouillot A]]
-
[[Category: Chung, C]]
+
[[Category: Chung C]]
-
[[Category: Delannee, D]]
+
[[Category: Delannee D]]
-
[[Category: Dudit, Y]]
+
[[Category: Dudit Y]]
-
[[Category: Gellibert, F]]
+
[[Category: Gellibert F]]
-
[[Category: Huet, P]]
+
[[Category: Huet P]]
-
[[Category: Krysa, G]]
+
[[Category: Krysa G]]
-
[[Category: Lamotte, Y]]
+
[[Category: Lamotte Y]]
-
[[Category: Lewis, A]]
+
[[Category: Lewis A]]
-
[[Category: Mirguet, O]]
+
[[Category: Mirguet O]]
-
[[Category: Nicodeme, E]]
+
[[Category: Nicodeme E]]
-
[[Category: Trottet, L]]
+
[[Category: Trottet L]]
-
[[Category: Witherington, J]]
+
[[Category: Witherington J]]
-
[[Category: Antagonist]]
+
-
[[Category: Epigenetic reader]]
+
-
[[Category: Histone]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Transcription]]
+

Current revision

The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand

PDB ID 4bw4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bw4"
Personal tools