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4bq8

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Current revision (07:21, 31 August 2022) (edit) (undo)
 
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<StructureSection load='4bq8' size='340' side='right'caption='[[4bq8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4bq8' size='340' side='right'caption='[[4bq8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bq8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bq8]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQ8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bq6|4bq6]], [[4bq7|4bq7]], [[4bq9|4bq9]], [[4bqb|4bqb]], [[4bqc|4bqc]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bq6|4bq6]], [[4bq7|4bq7]], [[4bq9|4bq9]], [[4bqb|4bqb]], [[4bqc|4bqc]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq8 OCA], [http://pdbe.org/4bq8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4bq8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bq8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq8 OCA], [https://pdbe.org/4bq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4bq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bq8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[http://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
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[[https://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[https://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
 
[[Category: Aricescu, A R]]
[[Category: Aricescu, A R]]
[[Category: Bell, C H]]
[[Category: Bell, C H]]

Current revision

Crystal structure of the RGMB-NEO1 complex form 3

PDB ID 4bq8

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