This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4bik

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:52, 20 December 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='4bik' size='340' side='right'caption='[[4bik]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
<StructureSection load='4bik' size='340' side='right'caption='[[4bik]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4bik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27335 Atcc 27335] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIK FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4bik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_intermedius Streptococcus intermedius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIK FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bik OCA], [http://pdbe.org/4bik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bik RCSB], [http://www.ebi.ac.uk/pdbsum/4bik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bik ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.494&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bik OCA], [https://pdbe.org/4bik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bik RCSB], [https://www.ebi.ac.uk/pdbsum/4bik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bik ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref>
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
+
[https://www.uniprot.org/uniprot/Q9LCB8_STRIT Q9LCB8_STRIT]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 21:
==See Also==
==See Also==
*[[CD59|CD59]]
*[[CD59|CD59]]
 +
*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Atcc 27335]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Brooks, N J]]
+
[[Category: Streptococcus intermedius]]
-
[[Category: Bubeck, D]]
+
[[Category: Brooks NJ]]
-
[[Category: Johnson, S]]
+
[[Category: Bubeck D]]
-
[[Category: Lea, S M]]
+
[[Category: Johnson S]]
-
[[Category: Smith, R A.G]]
+
[[Category: Lea SM]]
-
[[Category: Cholesterol dependent cytotoxin]]
+
[[Category: Smith RAG]]
-
[[Category: Complement]]
+
-
[[Category: Immune system]]
+
-
[[Category: Membrane attack complex]]
+

Current revision

Structure of a disulfide locked mutant of Intermedilysin with human CD59

PDB ID 4bik

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bik"
Personal tools