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4bf5

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<StructureSection load='4bf5' size='340' side='right'caption='[[4bf5]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='4bf5' size='340' side='right'caption='[[4bf5]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila_subsp._hydrophila Aeromonas hydrophila subsp. hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BF5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeromonas_hydrophila_subsp._hydrophila Aeromonas hydrophila subsp. hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BF5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4beq|4beq]], [[4beu|4beu]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bf5 OCA], [https://pdbe.org/4bf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bf5 RCSB], [https://www.ebi.ac.uk/pdbsum/4bf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bf5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bf5 OCA], [http://pdbe.org/4bf5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bf5 RCSB], [http://www.ebi.ac.uk/pdbsum/4bf5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bf5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0KLG5_AERHH A0KLG5_AERHH]] Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids (By similarity).[HAMAP-Rule:MF_01201]
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[https://www.uniprot.org/uniprot/BSR_AERHH BSR_AERHH] Amino-acid racemase able to utilize a broad range of substrates. Reversibly racemizes ten of the 19 natural chiral amino acids known, including both non-beta-branched aliphatic amino acids (Ala, Leu, Met, Ser, Cys, Gln and Asn) and positively charged amino acids (His, Lys and Arg). Is not active on negatively charged (Glu and Asp) or aromatic (Tyr, Trp and Phe) amino acids and displays minimal activity towards beta-branched aliphatic (Ile, Val and Thr) substrates (PubMed:24419381). Enables bacteria to produce and release extracellular non-canonical D-amino acids (NCDAAs) that regulate diverse cellular processes (By similarity).[UniProtKB:Q9KSE5]<ref>PMID:24419381</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Aeromonas hydrophila subsp. hydrophila]]
[[Category: Aeromonas hydrophila subsp. hydrophila]]
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[[Category: Alanine racemase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Carrasco-Lopez, C]]
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[[Category: Carrasco-Lopez C]]
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[[Category: Hermoso, J A]]
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[[Category: Hermoso JA]]
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[[Category: D-amino acid]]
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[[Category: Isomerase]]
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Current revision

Structure of broad spectrum racemase from Aeromonas hydrophila

PDB ID 4bf5

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OCA

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