AMP-activated protein kinase
From Proteopedia
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== Function == | == Function == | ||
| - | '''AMP-activated protein kinase''' (AMPK) is a nuclear receptor which regulates cellular uptake of glucose, β-oxidation of fatty acids and biogenesis of glucose transporter thus playing a role in cellular energy homeostasis by phosphorylating key proteins. In response to low levels of ATP, AMPK activates energy-producing pathways and inhibits energy-consuming pathways. | + | '''AMP-activated protein kinase''' (AMPK) is a [[nuclear receptor]] which regulates cellular uptake of glucose, β-oxidation of fatty acids and biogenesis of glucose transporter thus playing a role in cellular energy homeostasis by phosphorylating key proteins. In response to low levels of ATP, AMPK activates energy-producing pathways and inhibits energy-consuming pathways. |
| + | See also [[AMPK signaling pathway]]. | ||
== Relevance == | == Relevance == | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of AMP-activated protein kinase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *AMPK α-1 subunit | ||
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| - | **[[4red]] - hAMPK α1 subunit (mutant) - human<br /> | ||
| - | **[[4f2l]] - rAMPK α1 subunit – rat<br /> | ||
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| - | *AMPK α-2 subunit | ||
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| - | **[[2h6d]] - hAMPK α2 subunit<br /> | ||
| - | **[[2ltu]] - hAMPK α2 subunit – NMR<br /> | ||
| - | **[[2yza]] - hAMPK α2 subunit (mutant) <br /> | ||
| - | **[[3aqv]] - hAMPK α2 subunit (mutant) + inhibitor<br /> | ||
| - | **[[6bx6]] – hAMPK kinase domain (mutant) + inhibitor<br /> | ||
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| - | *AMPK β-1 carbohydrate-binding domain | ||
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| - | **[[1z0m]], [[4yef]] – rAMPK + β-cyclodextrin - rat<br /> | ||
| - | **[[1z0n]] – rAMPK (mutant) + β-cyclodextrin <br /> | ||
| - | **[[4yef]] – rAMPK + glucosyl-cyclodextrin <br /> | ||
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| - | *AMPK β-2 carbohydrate-binding domain | ||
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| - | **[[2f15]] – hAMPK <br /> | ||
| - | **[[2lu3]] – rAMPK - NMR<br /> | ||
| - | **[[2lu4]] – rAMPK + glycosyl-cyclodextrin - NMR<br /> | ||
| - | **[[4y0g]] – rAMPK <br /> | ||
| - | **[[4yee]] – rAMPK + glycosyl-cyclodextrin <br /> | ||
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| - | *AMPK γ-1 subunit | ||
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| - | **[[2uv4]], [[2uv5]] - hAMPK CBS 3+4 domains + AMP<br /> | ||
| - | **[[2uv6]], [[2uv7]] - hAMPK CBS 3+4 domains (mutant) + AMP<br /> | ||
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| - | *AMPK α-1+β-2+γ-1 | ||
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| - | **[[2v8q]], [[4eai]] – rAMPK + AMP<br /> | ||
| - | **[[2v92]], [[2v9j]], [[4eaj]] – rAMPK + AMP + ATP<br /> | ||
| - | **[[2y8l]], [[2y8q]] – rAMPK + ADP <br /> | ||
| - | **[[2ya3]] – rAMPK + coumarin-ADP + AMP<br /> | ||
| - | **[[4rew]] – hAMPK (mutant) + AMP <br /> | ||
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| - | *AMPK α-1+β-1+γ-1 | ||
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| - | **[[4eal]] – rAMPK + AMP<br /> | ||
| - | **[[4eak]] – rAMPK + ATP <br /> | ||
| - | **[[4eag]] – SNF1A/rAMPK β-1 γ-1 + ATP <br /> | ||
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| - | *Phosphorylated AMPK α-1+β-2+γ-1 | ||
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| - | **[[4cfh]] – rAMPK + AMP + staurosporine <br /> | ||
| - | **[[4rer]] – hAMPK (mutant) + AMP + staurosporine + cyclodextrin<br /> | ||
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| - | *Phosphorylated AMPK α-1+β-1+γ-1 | ||
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| - | **[[6c9f]] – hAMPK + activator<br /> | ||
| - | **[[6c9g]], [[6c9h]], [[6c9j]] – hAMPK (mutant) + activator<br /> | ||
| - | **[[4qfg]] – rAMPK (mutant) + AMP + staurosporine <br /> | ||
| - | **[[5ufu]], [[6e4u]], [[6e4t]], [[6e4w]] – rAMPK + AMP + ADP + staurosporine + activator<br /> | ||
| - | **[[4qfr]], [[4qfs]], [[5t5t]] – rAMPK (mutant) + AMP + ADP + staurosporine + activator<br /> | ||
| - | **[[5kq5]] – rAMPK + AMP + ADP + staurosporine + activator<br /> | ||
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| - | *Phosphorylated AMPK α-2+β-1+γ-1 | ||
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| - | **[[4cfe]], [[5iso]], [[4cff]], [[6b12u]] – hAMPK + AMP + staurosporine + benzimidazole derivative<br /> | ||
| - | **[[4zhx]], [[5ezv]] – hAMPK + AMP + staurosporine + furan-2-posphonic derivative<br /> | ||
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| - | *Phosphorylated AMPK α-2+β-2+γ-1 | ||
| - | **[[6b2e]] – hAMPK + AMP + staurosporine + activator<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Li X, Wang L, Zhou XE, Ke J, de Waal PW, Gu X, Tan MH, Wang D, Wu D, Xu HE, Melcher K. Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res. 2014 Nov 21. doi: 10.1038/cr.2014.150. PMID:25412657 doi:http://dx.doi.org/10.1038/cr.2014.150
